Bilge DEBELEÇ BÜTÜNER
Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Biyoteknoloji Anabilim Dalı
Araştırma alanları: Sağlık Bilimleri, Temel Bilimler, Eczacılık, Yaşam Bilimleri, Moleküler Biyoloji ve Genetik, Eczacılık Teknolojisi, Farmasötik Biyoteknoloji, Kanser Moleküler Biyolojisi, Sitogenetik, Tıp
Yayınlar
- Overview of Delivery Methods for Gene Editing (2026)
- Differential regulation of EMT-related pathways by inflammatory microenvironment in 3D prostate spheroids and tumor-stroma interaction models (2026)
- In vivo delivery strategies for therapeutic CRISPR genome editing (2026)
- Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness, Transfection Efficiency, and Biocompatibility (2025)
- Semi-synthetic sapogenin derivatives inhibit inflammation-induced tumorigenic signaling alterations in prostate carcinogenesis (2025)
- Semi-synthetic sapogenin derivatives inhibit inflammation-induced tumorigenic signaling alterations in prostate carcinogenesis (2024)
- NKX3.1 Expression Contributes to Epithelial–Mesenchymal Transition of Prostate Cancer Cells (2023)
- Androgen receptor contributes to repairing DNA damage induced by inflammation and oxidative stress in prostate cancer (2023)
- Evaluation of Borax Pentahydrate as a Novel Antiangiogenic Agent (2023)
- Oligonükleotid İlaçlar ve Gen Taşıyıcı Sistemler (2022)
- Activation of distinct antiviral T-cell immunity: A comparison of bi- and trispecific T-cell engager antibodies with a chimeric antigen receptor targeting HBV envelope proteins (2022)
- Interaction of OGG1 with NKX3.1 due to oxidative DNA damage (2021)
- Additional file 1 of Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids (2021)
- Additional file 1 of Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids (2021)
- SIRT1 siRNA-loaded lipid nanoparticles enhanced doxorubicin-induced cell death in prostate cancer cell lines (2021)
- Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids (2021)
- Development of SIRT1 siRNA-carrying liposomes for treatment of prostate cancer (2020)
- Evaluation of the effect of solid and cationic lipids on siRNA delivery systems (2020)
- Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids (2020)
- Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids (2020)
- Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds (2020)
- Ferutinin content and cytotoxic effects of various Ferula L. species on prostate cancer (PC-3) cell line (2020)
- Cytotoxic Activity of Sesquiterpenoids Isolated from Endemic Ferula tenuissima Hub.-Mor & Peşmen (2019)
- Evaluation of the cationic solid lipid nanoparticlescarrying siRNA against EphA2 receptor as non-viraldelivery systems (2019)
- Oxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Cancer (2019)
- Nutlin3a-Loaded Nanoparticles Show Enhanced Apoptotic Activity on Prostate Cancer Cells (2019)
- Nutlin3a Contributes to the Cytoplasmic Retention of Androgen Receptor (2018)
- NEW HETEROCYCLIC COMPOUNDS WITH ANTILEISHMANIAL ACTIVITY: DESIGN, SYNTHESIS, BIOACTIVITY AND MOLECULAR MODELLING STUDIES (2018)
- Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis (2018)
- 3D Cell Culture Model for Prostate Cancer Cells to Mimic Inflammatory Microenvironment (2018)
- Aşılar (2018)
- Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162] (2018)
- Cytotoxic Activity of Daucane Sesquiterpene Esters Isolated From Endemic Ferula tenuissima HUB. MOR& PEŞMEN (2018)
- Detection of 8-OHdG as a diagnostic biomarker (2018)
- OGG1 Does not Interact with NKX3.1 and AR to Repair 8-OHdG Base Damage in LNCaP Cells (2018)
- Quantitative Measurements of DNA Damage in Diagnosis and Treatment (2018)
- Inflammatory Microenvironment-Mediated E-Cadherin Decrease Induces Migration in LNCaPs (2018)
- Inflammatory Microenvironment-MediatedE-Cadherin Decrease Induces Migration in LNCaPs (2018)
- Role Of Inflammatory Microenvironment In T Cell CancerImmunotherapy (2017)
- STAMP2 Effect on Inflammatory Microenvironment in the Development of Prostate Cancer (2017)
- Characterization of Cycloartane-Type Sapogenol Derivatives for Prostate Cancer Chemoprevention (2017)
- Use of Non-steroidal Anti-inflammatory Drugs for Chemoprevention of Inflammation-induced Prostate Cancer (2017)
- European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (2017)
- Ferula tenuissima Hub Mor Peşmen Köklerinden Elde Edilen Sekonden Metabolitlerin PC 3 Hücre Hattı Üzerinde Sitotoksik Etkisi (2016)
- Ferula tenuissima hub Mor Peşmen Köklerinden Elde Edilen Sekonder Metabolitlerinin PC 3 Hücre Hattı Üzerinde Sitotoksik Etkisi (2016)
- Androgen Responce is Required for DNA Damage responce in oxidative stress conditions (2016)
- Androgen Responce is Required for DNA Damage Responce in Oxidative Stress Conditions (2016)
- Automated Cell Based Quantitation of 8 OHdG Damage (2016)
- Anti inflammatory effect of semi synthetıic astragalus saponıns on prostate cancer (2015)
- Semi synthetic Astragalus saponins inhibit inflammation induced carcinogenic mechanisms in LNCaP prostate cancer cells (2015)
- Quantitating 8 OHdG damage in prostate cancer as a marker of genomic heterogeneity (2015)
- Synthesis Characterization and Bioactivity Studies of Novel Thiazolopyrimidine Derivatives as Potential Antileishmanial PTR1 Enzyme Inhibitors (2015)
- Androgen Receptor plays role in menadione mediated 8OH dG damage leading to genomic heterogenity in prostate cancer Measurement of 8OH dG damage as a diagnostic tool (2015)
- Synthesis and Biological Evaluation of Pyridinium Hydrazone Derivatives as Potential Antileismanial PTR1Inhibitors (2015)
- Inflammation contributes to NKX3.1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression (2015)
- Redox control of protein degradation (2015)
- LOSS OF ANDROGEN SIGNALING RESULTS IN ABROGATED DNA DAMAGE RESPONSE IN INFLAMMATORY MICROENVIRONMENT (2015)
- Semi synthetic Astragalus saponins inhibit inflammation induced B catenin pathway activation and migration in LNCaP prostate cancer cells (2015)
- The redox biology network in cancer pathophysiology and therapeutics (2015)
- Türkiye’de Doğal Yayılış Gösteren Ferula L. Taksonlarının PC-3 Üzerinde Sitotoksik Etkileri (2014)
- SIRT1 sirna loaded cationic liposomes showed enhanced cell death of Prostate Cancer Cells with different p53 expression patterns (2014)
- NKX3.1 binding to GPX2, QSCN6, SOD1, and SOD2 promoters contributes to antioxidant response regulation via transactivation (2014)
- TNF alpha-Mediated Loss of beta-Catenin/E-Cadherin Association and Subsequent Increase in Cell Migration Is Partially Restored by NKX3.1 Expression in Prostate Cells (2014)
- HOXB13 contributes to G1/S and G2/M checkpoint controls in prostate (2014)
- Oksidatif stres regülasyonunun bozulmasında inflamasyon ile indüklenen NKX3 1 protein kaybının rolü (2013)
- Inflammatory Microenvironment Resulted in Abrogated B Catenin Signaling and Increased Cell Migration (2012)
- Inflammation-Mediated Abrogation of Androgen Signaling: An In Vitro Model of Prostate Cell Inflammation (2012)
- Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells (2012)
- Acute inflamation induced molecular alterations contribute prostatic tumorigenesis (2011)
- Ubiquitously Expressed Hematological and Neurological Expressed 1 Downregulates Akt-Mediated GSK3 beta Signaling, and Its Knockdown Results in Deregulated G2/M Transition in Prostate Cells (2011)
- HoxB13 associates with cell cycle regulators arrests cells at G1 S transition and its knockdown drives prostate cancer cells (2011)
- Inflammation results in loss of androgen receptor consequently uncontrolled proliferation in prostate cells (2011)
- Loss of NKX3 1 by Inflammatory Microenvironment Resulted in Uncontrolled Proliferation in Prostate Cells (2011)
- NKX3.1 contributes to S phase entry and regulates DNA damage response (DDR) in prostate cancer cell lines (2011)
- An Inflammation Model for Studing NKX3 1 Tumor Suppressor Function in LNCaP Cells (2010)
- ROS mediated DNA damage by topoisomerase inhibitors isolated from endemic Alkanna cappadocica (2010)
- p53 and AR downregulation mediated by cytokines in prostatic inflammatory atrophy model (2010)
- Functional characterization of HOXB13 targrts in prostate (2010)
- NKX3 1 abrogates DDR and promotes growth arrest in prostate cell lines (2009)
- Recombinant protein production of prostate tissue spesific NKX3 1 and STAMP1 proteins (2009)
- Identification of transcriptional targets of NKX3 1 (2009)
- HN1 An EGF responsive gene regulates cell cycle in prostate cancer (2009)
- Ectopic expression of NKX3 1 blocks DNA damage related H2AX phosphorylation and promotes growth arrest in prostate cancer cell lines (2008)
- Endemik Alkanna türlerinden izole edilen DNA Topoizomeraz I inhibitörlerinin DNA hasarı üzerine etkisi (2008)
- PC 3 prostat kanseri hücre hattında HN1 geninin karakterizasyonu (2008)
- Mutant Telomeric Repeats in Yeast Can Disrupt the Negative Regulation of Recombination-Mediated Telomere Maintenance and Create an Alternative Lengthening of Telomeres-Like Phenotype (2008)
- Is NKX3 1 a balancing factor between cell survival and apoptosis (2007)
- EGE VE AKDENI Z BO LGESI NDE U ROPATOJEN ESCHERICHIA COLI KO KENLERI NI N FLOROKI NOLONLARA DUYARLILIG I (2007)
- MUTASYON DNA HASARI ONARIM MEKANİZMALARI VE KANSERLE İLİŞKİSİ (2006)
- Recombinational telomere elongation in telomerase deletion mutant of Kluveromyces lactis (2005)
- Mutasyon , dna hasarı ,onarım mekanizmaları ve kanserle ilişkisi : mutation, dna damage, repair mechanisms and the relation of cancer (1962)