European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Makaleler > Tam Makale · 2017
Yazarlar: Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Gorlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vinal, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertran, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, Joao G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge DEBELEÇ BÜTÜNER, Irundika H. K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Peter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Forstermann, Rashid Giniatullin, Zoltan Giricz, Aniko Gorbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustin, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Durr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami KORKMAZ, Rafal Koziel, Damir Kracun, Karl-Heinz Krause, Vladimir Kren, Thomas Krieg, Joao Laranjinha, Antigone Lazou, Huige Li, Antonio Martinez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Veronica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milkovic, Antonio Miranda-Vizuete, Milos Mojovic, Maria Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Munzel, Vladimir Muzykantov, Isabel T. N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Gratiela G. Pircalabioru, Henrik E. Poulsen, Shlomo Sasson
Redox Biology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2017, cilt 13, ss 94-162
DOI: 10.1016/j.redox.2017.05.007
Özet
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.