Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids
Makaleler > Tam Makale · 2021
Yazarlar: Ezgi Oner, Mustafa KOTMAKÇI, Anne-Marie Baird, Steven G. Gray, Bilge DEBELEÇ BÜTÜNER, Emir Bozkurt, Ayşe Gülten KANTARCI, Stephen P. Finn
JOURNAL OF NANOBIOTECHNOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2021, cilt 19, ss 71-71
DOI: 10.1186/s12951-021-00781-z
Özet
Background: siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed.