Vildan ALPTÜZÜN

Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Anabilim Dalı

Research areas: Health Sciences, Pharmacology and Therapeutics, Natural Sciences, Life Sciences, Basic Pharmaceutics Sciences, Chemistry, Biochemistry, Professional Sciences, Pharmaceutical Chemistry, Molecular Biology and Genetics

Publications

• Biological evaluation of thiazolopyrimidine derivatives as novel heterocyclic compounds against promastigote and amastigote-like forms of Leishmania infantum and Leishmania tropica (2026)
• Synthesis and inhibitory activity of novel N-phenethylpiperidinehydrazide hydrazones against acetylcholinesterase, butyrylcholinesterase, and β-Amyloid (1–42) as potential anti-Alzheimer agents (2026)
• Synthesis, Bioactivity and Molecular Modeling Studies on Benzimidazole Derivatives and Its Isosteres as Potent AChE / BChE and GSK3β Inhibitors for Alzheimer's Disease (2026)
• 3-(1H-pyrazole-1-yl/1H-1,2,4-triazole-1-yl)-N-propananilide derivatives: Design, Synthesis and Neuroprotectivity Potential Against 6-OHDA Induced Neurotoxicity Model (2024)
• Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition (2023)
• N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity (2023)
• The antibacterial activity of photodynamic agents against multidrug resistant bacteria causing wound infection (2022)
• Design, synthesis, acetylcholinesterase, butyrylcholinesterase, and amyloid-β aggregation inhibition studies of substituted 4,4ʹ-diimine/4,4ʹ-diazobiphenyl derivatives (2022)
• N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimers disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity (2022)
• Design, synthesis, in vitro – In vivo biological evaluation of novel thiazolopyrimidine compounds as antileishmanial agent with PTR1 inhibition (2022)
• Photoinactivation Efficiency of Cationic Porphyrin Derivatives Against Multidrug-Resistant Wound Pathogens (2021)
• A Novel Molecule: 1‐(2,6 Dichlorobenzyl)‐4‐(2‐(2‐4‐hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA (2021)
• Potential Anti-Alzheimer Tacrine-Donepezil Hybrids with MTDL Profile (2020)
• Electrochemical Characteristics of a Novel Pyridinium Salt as a Candidate Drug Molecule and Its Interaction with DNA (2020)
• Design, synthesis, and in vitro biological evaluation of novel thiazolopyrimidine derivatives as antileishmanial compounds (2020)
• A Fusing Strategy Application: Towards Potent ChE Inhibitors with MTDL Profile (2019)
• 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor induces H2S formation. (2019)
• Antibacterial activity of porphyrin derivatives against multidrug-resistant bacteria. (2019)
• 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor induces H2S formation (2019)
• Antibacterial activity of porphyrin derivatives against multidrug-resistant bacteria (2019)
• Design and synthesis of 1,4-dihydropyridine derivatives aspotential cholinesterase inhibitorswith H2S releasing group (2018)
• Design, synthesis and biological activity studies on novel Tacrine-donepezile hybrides as MTDL against Alzheimer's Disease (2018)
• Ege Üniversitesi Eczacılık Fakültesi Eğitim Programı İyileştirme ve Geliştirme Projesi Kapsamında Yapılan Eczacılık Mesleği Görev Analizi Çalışması (2018)
• Ege Üniversitesi Eczacılık Fakültesi Lisans Eğitimi Programı’nın EczÇEP’le ve Ulusal Standartlarla Uyumunu Geliştirme, Öğretim ve Değerlendirme Süreçlerini İyileştirme Projesi (2018)
• Design, synthesis and biological activity studies on novel tacrine-donepezil hybrides as MTDL against Alzheimer’s disease (2018)
• A Merging Strategy Application: Tacrine-Benzylidenehydrazone Hybrids as Potent ChE Inhibitors with Metal Binding and Neuroprotective Properties (2018)
• Elimination of Multi-drug Resistant Acinetobacter baumannii Strain with Various Porphyrin Derivatives Stimulated by Red Light (2018)
• NEW HETEROCYCLIC COMPOUNDS WITH ANTILEISHMANIAL ACTIVITY: DESIGN, SYNTHESIS, BIOACTIVITY AND MOLECULAR MODELLING STUDIES (2018)
• A new multitargeted drug candidate in Alzheimer disease: 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor (2018)
• Multifunctional cholinesterase inhibitors for Alzheimer's disease: Synthesis, biological evaluations, and docking studies of o/p‐propoxyphenylsubstituted‐1H‐benzimidazole derivatives (2018)
• A NEW MULTITARGETED DRUG CANDIDATE IN ALZHEIMER DISEASE: 1,4-DIHYDROPYRIDINE-BENZYLIDENHYDRAZON DERIVED AChE INHIBITOR (2018)
• Elimination of Multi-drug Resistant Acinetobacter baumannii Strain with Various Porphyrin Derivatives Stimulated by Red Light (2018)
• Synthesis, biological evaluation, and docking studies of some 5-chloro-2(3H)-benzoxazolone Mannich bases derivatives as cholinesterase inhibitors (2018)
• Synthesis and evaluation of pyridinium‐hydrazone derivatives as potential antitumoral agents (2018)
• Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus (2018)
• Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones (2018)
• Design, Synthesis and Biological Evaluation of Some Benzimidazole/Benzothiazole Derivatives as AChE/BuChE Inhibitors (2017)
• SYNTHESIS AND BIOLOGICAL EVALUATION OF ORTHO-PROPOXYPHENYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS BUCHE AGENTS (2017)
• Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli (2017)
• ACTIVITY AGAINST CARBAPENEM RESISTANT PSEUDOMONAS AERUGINOSA OF ANTIMICROBIAL PHOTODYNAMIC THERAPY (2017)
• Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli (2017)
• Mannich‐Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study (2017)
• Synthesis and Biological Evaluation of Some Piperidine Hydrazide-Hydrazone Derivatives as AChE/BuChE Inhibitors (2017)
• Photodynamic atmicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus (2017)
• SYNTHESIS AND BIOLOGICAL EVALUATION OF 9-BENZYLIDENE HYDRAZINO-1,2,3,4-TETRAHYDROACRIDINE DERIVATIVES AS POTENTIAL ACETYLCHOLINESTERASE INHIBITORS (2017)
• SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME QUINOXALINE DERIVATIVES AS CHOLINESTERASE INHIBITORS (2017)
• ALZHEİMER TEDAVİSİNDE ÇOK HEDEFLİ BİR İLAÇ ADAYI: 1,4-DİHİDROPİRİDİN-BENZİLİDENHİDRAZON TÜREVİ ASETİLKOLİN ESTERAZ İNHİBİTÖRÜ (2017)
• SYNTHESIS AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME 4-(3/4-NITROPHTHALIMIDO) BENZENESULFONAMIDE DERIVATIVES (2017)
• PHOTODYNAMIC ANTMICROBIAL ACTIVITY OF NEW PORPHYRIN DERIVATIVES AGAINST METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS (2017)
• Synthesis and Bilogical Evaluation of 9-Benzylidenehydrazino-1,2,3,4-tetrahydroacridine Derivatives (2017)
• Synthesis and Biological Evaluatıon of Ortho-Propoxyphenyl Substıtuted 1H-Benzimidazole Derivatives as Buche Agents (2017)
• Leader Compound Optimization Studies on 1H-Benzimidazole Derivatives for Alzheimer Disease (2017)
• Photoinactivation with Novel Porphyrin Derivatives: An in Vitro Study on Multi-drug Resistant Escherichia coli(Yeni Porfirin Türevleri İle Fotoinaktivasyon:Çoklu İlaç Dirençli Escherichia coli Üzerinde InVitro Çalışma ) (2017)
• MANNICH BASES OF BENZIMIDAZOLE DERIVATIVES AS METAL-CHELATING PROPERTIES FOR THE TREATMENT OF ALZHEIMER’S DISEAS (2017)
• Mannich-Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study (2017)
• 1H benzimidazole derivatives as butyrylcholinesterase inhibitors synthesis and molecular modeling studies (2016)
• Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors (2016)
• Synthesis, Biological Evaluation and Molecular Docking Study of Hydrazone-Containing Pyridinium Salts as Cholinesterase Inhibitors (2016)
• 1H-benzimidazole derivatives as butyrylcholinesterase inhibitors: synthesis and molecular modeling studies (2016)
• SYNTHESIS AND ACETYLCHOLINESTERASE INHIBITOR ACTIVITY STUDIES ON N BENZYL PIPERIDINE AND N BENZYL MORPHOLINE DERIVATIVES (2015)
• Synthesis and biological evaluation of pyridinium-hydrazone derivatives as potential antileishmanial PTR1 inhibitors (2015)
• Synthesis Characterization and Bioactivity Studies of Novel Thiazolopyrimidine Derivatives as Potential Antileishmanial PTR1 Enzyme Inhibitors (2015)
• Synthesis and Biological Evaluation of Pyridinium Hydrazone Derivatives as Potential Antileismanial PTR1Inhibitors (2015)
• SYNTHESIS AND BIOLOGICAL ACTIVITY STUDIES ON ACETOPHENONE HYDRAZONE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS (2015)
• SYNTHESIS AND BIOLOGICAL EVALUATION OF MANNICH BASES OF BENZIMIDAZOLE 2 PHENOL DERIVATIVES ASANTICHOLINESTERASE AGENTS (2015)
• Synthesis and cholinesterase inhibitory activity of some phenylacetamide derivatives bearing 1H-pyrazole and 1H-1,2,4-triazole (2015)
• Synthesis and acetylcholinesterase (AChE) inhibitory activity of some N-substituted-5-chloro-2(3H)- benzoxazolone derivatives (2014)
• Design Synthesis Biological Evaluation and MolecularModeling of 1H Benzimidazole Derivatives asAcetyl Butyrylcholinesterase Inhibitors (2014)
• Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors (2013)
• 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood–brain barrier (2013)
• Synthesis and acetylcholinesterase(AChE) inhibitory activity of some N-substituted-5-chloro-2(3H)-benzoxazolone derivatives (2013)
• Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors (2013)
• Synthesis and acetylcholinesterase AChE inhibitory activity of some N substituted 5 chloro 2 3H benzoxazolone derivatives (2013)
• Synthesis and cytotoxic evaluation of uracil C-Mannich bases (2012)
• Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives (2012)
• Alzheimer s Disease New promising compounds with multiple effects and blood brain mobility (2011)
• Synthesis and cytotoxic evaluation of uracil C-Mannich bases (2011)
• ACETHYLCHOLINESTERASE INHIBITOR ACTIVITY OF SOME QUATERNARY PYRIDINIUM HYDRAZONE DERIVATIVES (2010)
• Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with β-amyloid, acetylcholine, and butyrylcholine esterases (2010)
• 4-[(2E)-2-(4-Chlorobenzylidene)hydrazinylidene]-1-methyl-1,4-dihydropyridine monohydrate (2010)
• Synthesis and Antimicrobial Activity of Some Pyridinium Salts (2009)
• strategies for development of new lead structures for inhibition of acetylcholinesterase (2008)
• Targeting acetylcholinesterase to treat neurodegeneration (2007)
• Synthesis and antimicrobial activities of some pyridinium salts (2006)
• Search for dual function inhibitors for Alzheimer’s disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Aβ fibril formation inhibition capacity (2005)
• A NEW CYCLOPENTANOL AS A SIDE PRODUCT IN THE REDUCTION OF THE CHALCONE : ŞALKONUN REDÜKSİYONUNDA BİR YAN ÜRÜN OLARAK YENİ BİR SİKLOPENTANOL (2004)
• Synthesis and biological activity of pyridinium-type acetylcholinesterase inhibitors (2003)
• Cooperative Interactions at M2 Muscarinic Acetylcholine Receptors: Structure/Activity Relationships in Stepwise Shortened Bispyridinium- and Bis(Ammonio)Alkane-Type Allosteric Modulators (2003)
• Synthesis and antimicrobial activities of some pyridinium salts : bazı piridinyum tuzlarının sentez ve antimikrobiyal etkileri (1968)

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