Ramazan Kaan KAVAKLI

Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı Ve Hastalıkları Anabilim Dalı

Araştırma alanları: Sağlık Bilimleri, Tıp, Dahili Tıp Bilimleri, İç Hastalıkları, Hematoloji, Çocuk Sağlığı ve Hastalıkları, Onkoloji, Temel Tıp Bilimleri, Tıbbi Biyoloji, Pediatrik Hematoloji

<p>CURRICULUM VITAE (2025) <span style="color: red;">KAAN KAVAKLI, M.D.</span></p><p><br></p><p><strong>HOME ADDRESS:</strong></p><p>SOYAK - Mavişehir Sitesi B bölgesi. 6523. Sokak B-4 Blok No: 21 Daire:12 Kat:3 Karşıyaka - Izmir – TR-35550 - Turkey</p><p>E-mail: <a href="mailto:kaan.kavakli61@gmail.com" rel="noopener noreferrer" target="_blank">kaan.kavakli61@gmail.com</a></p><p><strong>Mobile and Whats Appl (24 hours): + 90 542 432 87 38</strong></p><p><br></p><p><strong>BUSINESS ADDRESS:</strong></p><p>Ege University Children’s Hospital Dept. Pediatric Hematology University Street TR-35100 Bornova- Izmir- Turkey</p><p>Phone: + 90 232 390 10 17</p><p>Fax: + 90 232 388 99 00</p><p>E-mail: <a href="mailto:kaan.kavakli@ege.edu.tr" rel="noopener noreferrer" target="_blank">kaan.kavakli@ege.edu.tr</a></p><p><br></p><p>DATE OF BIRTH : March 3<sup>rd</sup>, 1961 (Turkey)</p><p>MARITAL STATUS: Married</p><p>LANGUAGES SPOKEN: English, Turkish</p><p><strong>INTERESTED FIELDS: Hemostasis and Thrombosis, Congenital Bleeding Disorders, Hemophilia treatment, Gene Therapy,</strong></p><p><strong>International Clinical Trials (Phases 1-2-3-4), </strong></p><p><br></p><p><strong><u>WORK EXPERIENCE </u></strong></p><p><br></p><p><strong>11/2021 – Today Professor of Pediatrics and Pediatric Hematology</strong></p><p>11/2018 – 11/2021 Chairman, Dept. Pediatrics Ege University Medical Faculty, Izmir, Turkey</p><p>07/2002-11-2018 Professor of Pediatrics and Pediatric Hematology</p><p>2002-2006: Chairman, Hemophilia Subcommittee of Turkish Hematology Association</p><p>1998-Today: Chairperson, Research Ethics Committee of Ege University Hospital</p><p>1998-Today: Chairman, Dept. Pediatric Hematology, Medical School of Ege University</p><p><strong>9/1996-3/1997: Working and visiting in Angelo Bianchi Bonomi Hemophilia and Thrombosis center in Milano, Italy.</strong></p><p>6/1995-Today: Pediatric Hematologist, Dept. Pediatrics, Ege University Hospital</p><p>1/1991-4/1991: “Visiting Residency” in Pediatrics, University of Wisconsin, Madison, USA</p><p>11/1986- 10/1991: Residency in Pediatrics, Ege University Hospital, Izmir</p><p>8/1985-11/1986: General Practitioner, Ayvalik State Hospital,Turkey</p><p>3/1984- 8/1985: General Practitioner, Military Hospital, Ağri, Turkey</p><p>7/1983- 3/1884: General Practitioner, Savur, Mardin, Turkey</p><p><strong><u> </u></strong></p><p><strong><u> </u></strong></p><p><strong><u> </u></strong></p><p><strong><u>NGO TASKS:</u></strong></p><p><strong><u> </u></strong></p><p>General Director 2005 – Today <strong> </strong>Hemophilia Federation (of Turkey)</p><p><br></p><p><strong>Director 2016 – Today Thrombosis Hemostasis and Angiology Association (of Turkey)</strong></p><p><br></p><p>Director <strong> </strong>1996 – Today<strong> </strong>Ege Hemophilia Society</p><p><strong><u> </u></strong></p><p><strong><u> </u></strong></p><p><strong><u> </u></strong></p><p><strong><u>EDUCATIONAL BACKGROUND</u></strong></p><p><u> </u></p><p>7/2002: Certified for Professorship in Pediatrics and Faculty Member of Ege University Medical Faculty</p><p>11/1995: Certified for Ass. Professorship in Pediatrics.</p><p>2/1992- 5/ 1995: Certified in Pediatric Hematology, Ege University Hospital</p><p>11/1986- 10/1991: Certified in Pediatrics</p><p>6/1983: Graduated from Ege University Medical School with degree of doctor of medicine.</p><p><br></p><p><br></p><p><strong><u> </u></strong></p><p><strong><u>PUBLICATIONS</u> </strong> (2025)</p><p><br></p><p>Publications indexed by PubMed: 200</p><p><br></p><p>Publication in an indexed by Web of Science: 300</p><p><br></p><p><strong>Citations determined by SCI: 4200</strong></p><p><br></p><p><strong>H – index 29</strong></p><p><br></p><p><br></p><p><em><u> </u></em></p><p><em><u> </u></em></p><p><em><u> </u></em></p><p><em><u> </u></em></p><p><em><u> </u></em></p><p><em><u> </u></em></p><p><strong>SOME SELECTED PUBLICATIONS</strong></p><p><br></p><ol><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Cuker A, <strong><u>Kavakli K</u></strong>, Frenzel L, et al. Gene therapy with Fidanococog Fitoparvovec in adult haemophilia-B. <strong>New England J Medicine</strong></li></ol><p>2024; 391: 1108-1118.</p><ol><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Young G, Srivastava A, <strong><u>Kavakli K,</u></strong> et al. Efficacy and safety of Fitusuran for inhibitor patients. ATLAS-INH study. <strong>Lancet</strong> 2023; 29 Mart, 2023.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Srivastava A, Rangarajan S, <strong><u>Kavakli K,</u></strong> et al. Fitusuran prophylaxis in people with HA or HB without inhibitors. <strong>Lancet Haematology</strong> 2023, 29 Mart 2023.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Shapiro AD, Anghaikuri P, Astermark J, Benson G, <strong>Kavakli K</strong>, et al. Subcutaneous concizumab prohylaxis in HA and HA/HB with inhibitors: phase-2 trail results. <strong>Blood</strong> 2019; 134: 1973-1982.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Mancuso EM, Male C, Kenet G, <strong>Kavakli K,</strong> et al. Prohylaxis in children with hemophilia in an evolving treatment landscape. <strong>Haemophilia</strong> 2021; 27: 889-896.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Peyvandi F, Mannucci PM,<strong>Kavakli K</strong>, et al. A randomised trial of factor FVIII and neutralizing antibodies in Hemophilia A. (Sippet Study<strong>). N Engl J Med 2016; 374: 2054-2064.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u><strong>, </strong>Smith L, et al.<strong> </strong>Once weekly prophylactic treatment vs. on-demand treatment with nonacog alfa in patients with moderately severe to severe hemophilia B. <strong>Haemophilia 2016; 29 Jan 2016; 1-8.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u>, Yang G, et al. Prophylaxis vs. on-demand treatment with BAY 81-8973, a full-length plasma protein-free rFVIII product: results from a randomized trial (LEOPOLD II<strong>). J Thromb Haemost 2015; 13: 360-369.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Tiede A, Brand B, Fischer R, <u>Kavakli K.</u> Enhancing the PK properties of rFVIII: first in-human trial of glycol-PEGlated rFVIII in patients with hemophilia-A. <strong>J Thromb Haemost 2013; 11: 670-678</strong>.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Kavakli K, et al. Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia. Ann <strong>Nucl Med 2012; 26: 41-46.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Leisinger C, Gringeri A, Antmen B, <u>Kavakli K</u>, et al. Anti-inhibitor coagulant complex prophylaxis in hemophilia with inhibitors. <strong>N Engl J N Med 2011; 365: 1684-1692.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Akin M, <u>Kavakli K</u>. Laboratory Diagnosis and management of vonWillebrand disease in Turkey: Izmir experience. <strong>Semin Thromb Hemost 2011; 37: 581-586.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K,</u> et al. The value of early treatment in patients with hemophilia and inhibitors. <strong>Haemophilia 2010; 16: 487-94.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli et al</u>. Long-term evaluation of chromosomal breakages after radioisotope synovectomy for treatment of target joints in patients with hemophilia. <strong>Haemophilia 2010; 16: 474-78.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u>, Aydoğdu S, Taner M, et al. Radioisotope synovectomy with Rhenium 186 in hemophilic synovitis for elbows, ankles and shoulders. <strong>Haemophilia 2008 14; 518-523.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Fidanci ID, <u>Kavakli K</u>, Ucar C, et al. Factor 8 gene mutation profile of Turkish hemophilia A patients with inhibitors. <strong>Blood Coagul Fibrinolysis 2008; 19: 383-388</strong>.</li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Unuvar A, <u>Kavakli K</u>, Baytan B, et al. Low-dose immune tolerance induction for pediatric hemophilia patients with factor VIII inhibitors. <strong>Haemophilia 2008; 14: 315-322.</strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span>Astermark J, Oldenburg J, Carlson J, Pavlova A, <u>Kavakli K</u>, Berntorp E, Lefvert AK.</li></ol><p>Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. <strong>Blood 2006 108; 3739-3745. </strong></p><ol><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u>, Makris M, Zulfikar B, Erhardtsen E, Abrams ZS, Kenet G; NovoSeven trial (F7HAEM-1510) investigators. Home treatment of haemarthroses using a single dose regimen of recombinant activated factor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial. <strong>Thromb Haemost. 2006; 95: 600-605. </strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u>, Aydogdu S, Omay SB, Duman Y, Taner M, Capaci K, Memis A, Balkan C, Karapinar D. Long-term evaluation of radioisotope synovectomy with Yttrium 90 for chronic synovitis in Turkish haemophiliacs: Izmir experience. <strong>Haemophilia 2006;12:28-35. </strong></li><li data-list="ordered"><span class="ql-ui" contenteditable="false"></span><u>Kavakli K</u>, Aledort LA. Circumcision and Haemophilia: a perspective. <strong>Haemophilia 1998; 4 : 1</strong>-3.</li></ol>

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