Resveratrol attenuates doxorubicin-induced cellular damage by modulating nitric oxide and apoptosis
Makaleler > Tam Makale · 2012
Yazarlar: Gülperi ÖKTEM, Ayşegül UYSAL, Onur ORAL, Ebru SEZER, Murat OLUKMAN, Ayşe EROL, Serap Annette AKGÜR, Ayhan Bilir
Experimental and Toxicologic Pathology, ESCI İndekslerine Giren Dergi, Uluslararası, Emerging Sources Citation Index (ESCI), 2012, cilt 64, ss 471-479
DOI: 10.1016/j.etp.2010.11.001
Özet
Although doxorubicin (DOX) is a commonly used chemotherapeutic agent its clinical use is restricted due to its organ toxicities. The present investigation relates to reducing DOX induced side effects to the liver, kidney and ileum by usage of the antioxidant, anti-inflammatory agent, resveratrol (RES) and to investigate the role of nitric oxide synthase (NOS) in the process. Wistar rats were divided into four groups: control (saline i.p); DOX (20 mg/kg i.p), RES (20 mg/kg i.p) and DOX (20 mg/kg i.p) + RES (20 mg/kg i.p). Immunohistochemical activity of both iNOS and eNOS were evaluated after DOX treatment and ultrastructural changes such as cellular damage and mitochondrial degeneration were evaluated. Degenerative ultrastructural changes were demonstrated especially in the DOX treated group. Variations in biochemical marker levels of oxidative stress on ischemia in tissues were not observed. Our data indicate that RES may prevent cellular damage in the early phase of DOX induced toxicity. RES could be used with its beneficial effects during early cellular damage in organ toxicity after DOX treatment in cancer patients. (C) 2010 Published by Elsevier GmbH.