The relation of adiponectin and tumor necrosis factor a levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor beta, and tumor necrosis factor a gene polymorphism in adrenal incidentalomas
Articles > Article · 2009
Authors: E. HARMAN, M. KARADENIZ, Çığır BİRAY AVCI, A. ZENGI, Şevki ÇETİNKALP, Ahmet Gökhan ÖZGEN, F. SAYGILI, Afig BERDELİ, Cumhur GÜNDÜZ, CENGİZ YILMAZ
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, Journal Indexed in SCI Expanded, International, 2009, vol 32, pp 881-888
DOI: 10.3275/6279
Summary
Objective: The aim of our study was to demonstrate demographic characteristics, presence of inflammatory markers, distribution of angiotensin-converting enzyme (ACE), tumor necrosis factor (TNF), endothelial nitric oxide synthase (eNOS) genotypes and relations among these parameters in these patients and control subjects. Research design and methods: Study samples were collected from 50 patients with adrenal mass and 30 control groups. The eNOS, ACE, TNF-alpha, transforming growth factor (TGF)-beta genes polymorphisms, TNF-alpha, adiponectin levels were analysed in 50 unrelated Turkish patients with a diagnosis of adrenal incidentaloma (Al). Results: There was statistically significant difference between TNF-alpha levels of patient and controls (p=0.048). We have not detected the connection between TGF-beta, TNF-alpha, ACE, eNOS gene polymorphism with serum TNF-alpha and adiponectin levels. In this study, we demonstrated that there were significant differences for ACE genotypes in the patients when compared to the controls (p<0.05). The percentages of the ID, DID, 11 genotypes for ACE gene polymorphism in the patients group were 30.0, 13.0, 7.0%, respectively. Conclusions: According to different cases of eNOS, TGF-beta, ACE, and TNF-alpha gene genotypes; no statistical significant difference was found between basal cortisol, ACTH, DHEAS, metanephrine, renin, aldosterone, normetanephrine, 17-hydroxyprogesterone, 1 mg low-dose dexamethasone suppression test-cortisol response and Al size. In this study, I/D genotype was determined to be statistically higher in ACE gene in patients with Al (p=0.014). (J. Endocrinol. Invest. 32: 881-888, 2009) (C) 2009, Editrice Kurtis