Investigation of the synergistic effects of paclitaxel and herbal substances and endemic plant extracts on cell cycle and apoptosis signal pathways in prostate cancer cell lines
Articles > Article · 2018
Authors: Şiğva Doğan, Okcanoğlu Balci, Çığır BİRAY AVCI, Sunde YILMAZ SÜSLÜER, Ç Kayabaşi, B Turna, Y Dodurga, Oktay NAZLI, Cumhur GÜNDÜZ
Gene, Journal Indexed in SCI Expanded, International, WoS, 2018, vol 687, pp 261-271
DOI: 10.1016/j.gene.2018.11.049
Summary
Paclitaxel, which isolated from Taxes brevifolia, is recently started to be used against prostate cancer treatment and it is a very effective compound against cancer. In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tinctoria), which are known to have antic-arcinogenic effect on androgen-independent PC3 and DU145, and androgen-dependent VCaP prostate cancer cell lines, with paclitaxel on the expression of cell cycle signaling and apoptosis regulator genes.