Necil KÜTÜKÇÜLER

Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı Ve Hastalıkları Anabilim Dalı

Araştırma alanları: Sağlık Bilimleri, Tıp, Dahili Tıp Bilimleri, Çocuk Sağlığı ve Hastalıkları, Pediatrik İmmünoloji ve Allerji, Diğer, Tıbbi Genetik, Temel Bilimler, Yaşam Bilimleri, Diş Hekimliği

Yayınlar

Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation (2026)
B cells, autoimmunity, and innate immunity in 22q11.2 deletion syndrome: a two-center study and review of the literature (2026)
Unclassified Inborn Errors of Immunity Patients without any Pathogenic Variant in Targeted Next-Generation Sequencing: Long-Term Follow-up and Whole Exome Sequencing Results (2026)
MALT1 alternative splicing—A molecular rheostat for balancing immune activation and homeostasis (2026)
Exploring the role of NOD2 variants in pediatric undifferentiated recurrent fever: a clinical and functional perspective (2025)
Exploring the role of NOD2 variants in pediatric undifferentiated recurrent fever: a clinical and functional perspective (2025)
Transient hypogammaglobulinemia of infancy and unclassified syndromic immunodeficiencies are highly common in oesophageal atresia patients (2024)
Primary immune regulatory disorders (PIRD): expanding the mutation spectrum in Turkey and identification of sixteen novel variants (2024)
MHC Class II Deficiency: Clinical, Immunological, and Genetic Insights in a Large Multicenter Cohort (2024)
Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency (2024)
Facilitated Subcutaneous Immunoglobulin Treatment Increases the Quality of Life and Decreases the Number of Infections and Hospitalizations in Children with Primary Immunodeficiencies (2024)
Investigation of Phagocyte Functions in Pseudomonas-Colonized Cystic Fibrosis Patients (2024)
Analysis of IL-1β, TGF-β, IL-5, ACE, PTPN22 gene polymorphisms, and gene expression levels in Turkish children with IgA vasculitis (2024)
Investigation of Phagocyte Functions in Pseudomonas-Colonized Cystic Fibrosis Patients (2024)
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience (2023)
An Extraordinary Case of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) Syndrome Misdiagnosed as Juvenile Idiopathic Arthritis on Admission (2023)
Therapeutic modalities and clinical outcomes in a large cohort with LRBA deficiency and CTLA4 insufficiency (2023)
Eight years of follow-up experience in children with mendelian susceptibility to mycobacterial disease and review of the literature (2023)
Analysis of IL-1β, TGF-β, IL-5, ACE, PTPN22 gene polymorphisms, and gene expression levels in Turkish children with IgA vasculitis (2023)
Analysis of IL-1β, TGF-β, IL-5, ACE, PTPN22 gene polymorphisms, and gene expression levels in Turkish children with IgA vasculitis (2023)
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience (2023)
Transient hypogammaglobulinemia of infancy: Clinical and immunologic features of 385 cases. (2023)
Yaygın Değişken İmmün Yetmezlikte Tanımlanan Genetik Defektler (2023)
Dual Diagnosis of Trichohepatoenteric Syndrome and Lipoid Proteinosis in a Turkish Child (2023)
Alterations in B and NK cells highly correlate with disease severity in children with COVID-19 (2023)
Autoimmune Cytopenias Are Highly Associated with Inborn Errors of Immunity and They May Be the Initial Presentations in Cases without Severe Infections (2023)
Current Genetic Defects in Common Variable Immune Deficiency Patients on the Geography Between Europe and Asia (2023)
Analysis of IL-1β, TGF- Β, Il-5, ACE and PTPN22 Gene Polymorphisms and GEN Expression Levels in Turkish Chlidren with IgA Vasculitis (2023)
Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation (2022)
A Remarkable Case of Autoimmune Polyendocrinopathy, Candidiasis and Ectodermal Dystrophy Syndrome (APECED) misdiagnosed as Juvenile Idiopathic Arthritis on admission (2022)
INVESTIGATION OF PHAGOCYTE FUNCTIONS IN PSEUDOMONAS-COLONIZED CYSTIC FIBROSIS PATIENTS (2022)
COMBINED IMMUNODEFICIENCY DUE TO JAK3 MUTATION ASSOCIATED WITH REFRACTORY CMV INFECTION AND BCG-OSİ (2022)
Psödomanas Aeruginosa Kolonize Kistik Fibrozisli Hastaların Nötrofil Fonksiyonlarının Değerlendirilmesi (2022)
A Novel BLNK Gene Mutation in a Four-Year-Old Child Who Presented with Late Onset of Severe Infections and High IgM Levels and Diagnosed and Followed as X-Linked Agammaglobulinemia for Two Years (2022)
A Novel BLNK Gene Mutation in a Four-Year-Old Child Who Presented with Late Onset of Severe Infections and High IgM Levels and Diagnosed and Followed as X-Linked Agammaglobulinemia for Two Years (2022)
Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry (2022)
Comparing the levels of CTLA‐4‐dependent biological defects in patients with LRBA deficiency and CTLA‐4 insufficiency (2022)
Severe combined immunodeficiencies: Expanding the mutation spectrum in Turkey and identification of 12 novel variants (2022)
Özofagus atrezili hastalarda replasman ameliyatı öncesi immün yetmezlik sıklığı (2021)
Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; PLCG2): Striking clinical phenotypic overlap and difference (2021)
Eight years of follow-up experience in children with mendelian susceptibility to mycobacterial disease and review of the literature (2021)
COVID19 pandemisinin primer immün yetmezlik tanılı hastalar üzerinde etkisi (2021)
Erratum: X-linked agammaglobulinemia: investigation of clinical and laboratory findings, novel gene mutations and prevention of infective complications in long-term follow-up. (2021)
A Novel Homozygous TRNT1 Mutation in a Child with an Early Diagnosis of Common Variable Immunodeficiency Leading to Mild Hypogammaglobulinemia and Hemolytic Anemia (2021)
Combined immunodeficiency with marginal zone lymphoma due to a novel homozygous mutation in IL-21R gene and successful treatment with hematopoietic stem cell transplantation (2021)
X-linked agammaglobulinemia: investigation of clinical and laboratory findings, novel gene mutations and prevention of infective complications in long-term follow-up (2021)
X-linked agammaglobulinemia: ınvestigation of clinical and laboratory findings, novel gene mutations and prevention of ınfective complications in long-term follow-up. (2021)
Four diseases, PLAID, APLAID, FCAS3 and CVID and one gene (PHOSPHOLIPASE C, GAMMA-2; PLCG2 ): striking clinical phenotypic overlap and difference (2021)
Consensus Middle East and North Africa Registry on Inborn Errors of Immunity (2021)
X-linked agammaglobulinemia: ınvestigation of clinical and laboratory findings, novel gene mutations and prevention of ınfective complications in long-term follow-up (2021)
X-linked agammaglobulinemia: ınvestigation of clinical and laboratory findings, novel gene mutations and prevention of ınfective complications in long-term follow-up (2021)
Common variable immunodeficiency: familial inheritance and autoimmune manifestations in two siblings (2021)
A Novel Homozygous TRNT1 Mutation in a Child With an Early Diagnosis of Common Variable Immunodeficiency Leading to Mild Hypogammaglobulinemia and Hemolytic Anemia. (2021)
X-linked agammaglobulinemia: ınvestigation of clinical and laboratory findings, novel gene mutations and prevention of ınfective complications in long-term follow-up. (2021)
Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant (2021)
Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia (2021)
Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia (2021)
Consensus Middle East and North Africa Registry on Inborn Errors of Immunity (2021)
Eight years of follow-up experience in children with mendelian susceptibility to mycobacterial disease and review of the literature (2021)
Consensus Middle East and North Africa Registry on Inborn Errors of Immunity (2021)
Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia (2021)
LRBA VE CTLA-4 EKSIKLIĞI OLGULARINDA SOLUBLECD25 VE FOLIKÜLER T HÜCRE DÜZEYLERI HASTALIK AKTIVITESINI GÖSTERMEDE BAŞARILIDIR. (2020)
Correction to: the IL1RN Mutation Creating the Most-Upstream Premature Stop Codon Is Hypomorphic because of a Reinitiation of Translation (Journal of Clinical Immunology, (2020), 40, 4, (643-645), 10.1007/s10875-020-00770-1) (2020)
A Remarkable Coexistence of Systemic Capillary Leak Syndrome and Diabetes in an 11-Year-Old Boy: A Case Report and Review of the Literature (2020)
Autoantibody Positivity in Children with Chronic Diarrhea (2020)
The evaluation of malignancies in Turkish primary immunodeficiency patients a multicenter study (2020)
Periodic fever syndromes: a patient diagnosed with recurrent Kawasaki disease (2020)
Primer İmmün Yetmezliklerde İmmünoglobulin Replasman Tedavisi: Güncel Durum Raporu 2019 (2020)
Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant (2020)
Efficacy and quality of life assessment in the use of subcutaneous immunoglobulin treatment in children with primary immunodeficiency (2020)
LBRA VE CTLA-4 EKSIKLIKLERININ TANISINDA VE AYRIMINDA KLINIK OZELLIKLERIN VE IMMUNOLOJIK TESTLERIN DEĞERI. (2020)
ÇOCUK ROMATOLOJİ HASTALARINDA HASTANE MALNÜTRİSYONU VE MALNÜTRİSYON SKORLAMALARI (2020)
Romatoloji hastalarında hastane malnütrisyonu ve malnütrisyon skorları. (2020)
The IL1RN Mutation Creating the Most-Upstream Premature Stop Codon Is Hypomorphic Because of a Reinitiation of Translation (2020)
. IL21R defektine bağlı kombine immün yetmezlik zemininde gelişen marjinal zone lenfomalı olgu. (2019)
İnterlökin 12 / Interferon gamma yolak bozuklukları ve atipik mikobakteriyel enfeksiyonlara yatkınlık (2019)
Chronic granulamatous disease: Two decades of experience from a paediatric immunology unit in a country with high rate of consangineous marriages (2019)
A Novel TTC37 Mutation Causing Clinical Symptoms of Trichohepatoenteric Syndrome Such as Pyoderma Gangrenosum and Immunodeficiency Without Severe Diarrhea (2019)
Antı-β2 Glycoprotein I Antibodies in Children with Rheumatologic Disorders (2019)
Deficiency of Interleukin-1 Receptor Antagonist: A Case with Late Onset Severe Inflammatory Arthritis, Nail Psoriasis with Onychomycosis and Well Responsive to Adalimumab Therapy (2019)
Chapter 65. Constrictive Aspergillosis Pericarditis (2019)
Chapter 95. Early-Onset Inflammatory Bowel DiseaseNeslihan Edeer Karaca, Guzide Aksu, and Necil Kutukculer (2019)
Chapter 143. BCGosis and Hyperferritinemia (2019)
Chapter 43. Necrotizing Liver Granuloma (2019)
Constrictive aspergillosis pericarditis (2019)
Necrotizing liver granuloma (2019)
BCGosis and hyperferritinemia (2019)
Early-onset inflammatory bowel disease (2019)
PRIMARY IMMUNODEFICIENCY DISEASES AND MALIGNANCY IN TURKEY A MULTICENTER STUDY. (2019)
Genetically defined mutations in primary immunodeficiencies by new generation sequencing targeted gene method: results of 200 patients from one center in Western Turkey. (2019)
Meet the Expert. Malignancy Post Haematopoietic Stem Cell Transplant For Primary Immunodeficiency. Abatacept as a long-term targeted therapy for LRBA deficiency (2019)
TRNT1 DISEASE PRESENTING WITH CONGENITAL HEMOLYTIC ANEMIA AND HYPOGAMMAGLOBULINEMIA (2019)
Çocukluk Çağında Nadir Görülen Igg4 (İmmünglobulin G4) İlişkili Hastalık: Dört Hastanın Değerlendirilmesi. (2019)
Ege Üniversitesi Pediatrik İmmünoloji Bilim Dalı’xxnda Primer İmmün Yetmezliklerde Yeni Nesil Dizileme Hedeflenmiş Gen Yöntemi ile Moleküler Bozuklukların Araştırılması (2018 yılı sonuna dek tüm veriler) (2019)
Ataksi-telenjiektazi tanılı hastaların retrospektif olarak incelenmesi: İki merkez deneyimi. (2019)
COMBINED IMMUNODEFICIENCY WITH MARGINAL ZONE LYMPHOMA DUE TO A NOVEL HOMOZYGOUS MUTATION IN IL21R GENE. (2019)
INTERLEUKIN-12/INTERFERON-GAMMA PATHWAY DISORDERS AND PREDISPOSITION TO ATYPICAL MYCOBACTERIAL INFECTIONS (2019)
Ağır Kombine ve Kombine İmmun Yetmezliklerde Dirençli CMV enfeksiyonu: RAG1, ZAP70 Ve ORAI1 mutasyonları. (2019)
Genetically defined mutations in primary immunodeficiencies by new generation sequencing targeted gene method: results of 200 patients from one center in Western Turkey (2019)
Ege Üniversitesi Pediatrik İmmünoloji Bilim Dalı’xxnda Primer İmmün Yetmezliklerde Yeni Nesil Dizileme Hedeflenmiş Gen Yöntemi ile Moleküler Bozuklukların Araştırılması (2018 yılı sonuna dek tüm veriler) (2019)

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