İsmail Hakkı AKGÜN

Mühendislik Fakültesi, Biyomühendislik Bölümü, Biyomühendislik Anabilim Dalı

Research areas: Natural Sciences, Chemistry, Biotechnology, Engineering and Technology, Health Sciences, Chemical Engineering and Technology, Agricultural Sciences, Life Sciences, Analytical Chemistry, Chromatographic Analysis

Publications

• Aurantiochytrium limacinum as a natural and sustainable alternative source for squalene: a novel thin-layer chromatography method for squalene detection (2026)
• Performing Effective Calculations of Protein-Ligand Binding Free Energy with the Help of Molecular Dynamics Methods (2025)
• Semi-synthetic sapogenin derivatives inhibit inflammation-induced tumorigenic signaling alterations in prostate carcinogenesis (2025)
• Evaluation Secondary Metabolites Profiles of Aspergillus brasiliensis by Plug Extraction Method (2024)
• Semi-synthetic sapogenin derivatives inhibit inflammation-induced tumorigenic signaling alterations in prostate carcinogenesis (2024)
• Production of laccase enzyme via solid-state fermentation and its application in white and whole meal wheat bread (2024)
• Stypopodium Schimperi (Kützing) Verlaque&Boudouresque Makro-Alg Türü Metanol Ekstraksiyonu ve Çeşitli Fraksiyonlarının, 4T1 ve 67NR Meme Kanser Hücre Hatları Üzerine Etkilerinin İncelenmesi (2024)
• Oleuropeinin İnce Tabaka Kromatografisi Yöntemi ile Miktar Tayininin Gerçekleştirilmesi (2024)
• Peptidomimetik Yaklaşım ve Moleküler Modelleme Yöntemleri ile YAP-TEAD Kompleksi Oluşumunu İnhibe Edecek Peptidlerin Tasarlanması (2024)
• Designing Peptides To Prevent Yap-Tead Complex Formation By Integration of Non Canonical Amino Acids Into Rosetta Commons (2023)
• Zeytin Yaprağından Elde Edilen Oleuropeinin İnce Tabaka Kromatografisi Yöntemi ile Miktar Tayini (2023)
• Characterization of different chitosanases of Bacillus strains and their application in chitooligosaccharides production (2022)
• VLVS: A Knime Based Virtual Library Generation and Screening Workflow (2021)
• Screening of Natural Product and Natural Product like Molecules against SARS–CoV–2 Main Protease Using Molecular Modeling Methods (2021)
• Chemical composition and biological activities of Cypriot propolis (2021)
• Astragalus Trojanus Stev. Kesikli Kültürleri: Ph, Sükroz ve Kazein Hidrolizat Etkisi ile Sikloartan-tip Metabolit Birikimi (2019)
• Docking Simulations of Novel N-Acetyl-Tryptophan and Biphenyl-3-ol Derivatives on Acetylcholinesterase Enzyme (2018)
• Enhancement of stevioside production by using biotechnological approach in in vitro culture of Stevia rebaudiana (2018)
• Docking Simulations of Cyclic and Linear Peptides to Discover Novel ?vß3 Integrin Inhibitors (2018)
• Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis (2018)
• Optimization of precursor and elicitor utilization in batch cultures of Astragalus trojanus Stev. (2018)
• Investigation of Potential Usage of Some Natural Products on Various Enzyme Targets (2018)
• Enhancement of stevioside production by using biotechnological approach in in vitro culture of Stevia rebaudiana. (2018)
• Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis (2018)
• Qualitative and Quantitative Analysis of Astragalus trojanus Batch Cultures with the Effect of Potassium Nitrate, Glucose, Light and Temperature. (2018)
• Identification Strategies for Bioactive Secondary Metabolites of Fungal Origin (2017)
• Flexible Docking and Molecular Dynamic Simulations of Selected Virtual Biotransformation Reaction Products on IKKß (2017)
• Converted carotenoid production in Dunaliella salina by using cyclization inhibitors 2-methylimidazole and 3-amino-1,2,4-triazole (2017)
• Identification Strategies for Bioactive Secondary Metabolites of Fungal Origin (2017)
• Generation of Virtual Molecular Libraries by UsingUnusual Fragments for Lead Identification (2017)
• Production of GH11 xylanase for bakery industry by solid state fermentation (2017)
• In vitro commercial micropropagation of Stevia rebaudiana (Bertoni) (2017)
• Production of xylanase for breadmaking in submerged culture from laboratory scale to pilot scale (2017)
• Production of xylanase for breadmaking in submerged culture from laboratory scale to pilot scale (2017)
• Characterization of Cycloartane-Type Sapogenol Derivatives for Prostate Cancer Chemoprevention (2017)
• Docking Simulations of Virtual Biotransformation Reaction Products on Protein Kinase IKK (2016)
• Elicitor induced stevioside production, in vitro shoot growth, and biomass accumulation in micropropagated Stevia rebaudiana (2016)
• Plant Growth Regulator Effects on In Vitro Propagation and Stevioside Production in Stevia rebaudiana Bertoni (2016)
• Development of a technique for determination of biomolecular diffusion coefficients in microfludic systems (2015)
• On the Road to Designing New NF-?B Signal Pathway Inhibitors:Structure Activity Landscape Index (SALI) Network Analysis of Highly Active IKKß Enzyme Inhibitors (2015)
• Semi synthetic Astragalus saponins inhibit inflammation induced carcinogenic mechanisms in LNCaP prostate cancer cells (2015)
• Anti inflammatory effect of semi synthetıic astragalus saponıns on prostate cancer (2015)
• Astragaloside IV and Cycloastragenol Production Capacity of Astragalus trojanus Calli (2015)
• Development of a technique for determination of biomolecular diffusion coefficients in microfluidic systems (2015)
• Determination of clone lines having a high content of stevioside and rebaudioside A for in vitro commercial production of Stevia rebaudiana (2015)
• Astragaloside IV and cycloastragenol production in in vitro produced Astragalus trojanus Stev. (2015)
• Effect of lycopene cyclase inhibitors Nicotine 2 methyl imidasole and MAP on growth and carotenoid profile of Dunaliella salina (2013)
• Preparation of Cytotoxci Molecules From Cycloartanes (2013)
• Carotenoid accumulation in 2 Methyl Imidasole and Amitrole treated Dunaliella salina (2013)
• Carotenoid and Fatty Acid Compositions of an Indigenous Ettlia texensis Isolate (Chlorophyceae) Under Phototrophic and Mixotrophic Conditions (2013)
• Supercritical CO2 extraction of Alkanna species and investigating functional characteristics of alkannin-enriched yoghurt during storage (2012)
• Shoot proliferation and HPLC-determination of iridoid glycosides in clones of Gentiana cruciata L (2011)
• Farklı ekolojik çevrelerden izole edilen aktinomiset suşlarının aktinomisin D üretimleri (2011)
• Semi-Synthesis of Cytotoxic Molecules From Cycloartane Type Sapogenols (2011)
• Optimization of total alkannin yields of Alkanna tinctoria by using sub- and supercritical carbon dioxide extraction (2011)
• Induction of Gentiana cruciata hairy roots and their secondary metabolites (2011)
• Klonal Çoğaltılan Bazı Gentiana Türlerinde Agrobacterium rhizogenes Aracılığı ile Transforme Saçaklı Kök Kültürlerinin Oluşturulması ve Sekonder Metabolit İçeriklerinin Karşılaştırılması (2010)
• Cytotoxic Naphthoquinones from Alkanna cappadocica (2010)
• Chemistry and Biological Activities of Naphthoquinones from Alkanna cappadocica Boiss.& Bal (2009)
• Determination of polyphenolic constituents and biological activities of bark extracts from different Pinus species (2009)
• Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization (2009)
• Determination of Naphthazarin Derivatives in 16 Alkanna Species by RP-LC Using UV and MS for Detection (2009)
• Determination of iridoid glycosides in micropropagated plantets and hairy roots of Gentiana cruciata by reverse pahse HPLC (2008)
• Cytotoxic snd DNA Damage Effect of Topoisomerase Inhibitors Isolated From Endemic Alkanna Species on Cancer Cells (2008)
• Gentiana cruciata L.’de Agrobacterium rhizogenes aracılığı ile Transforme Saçaklı Kök Kültürlerinin Oluşturulması ve Sekonder Metabolit İçeriklerinin Karşılaştırılması. (2008)
• Determination of naptharazin derivatives in Turkish Alkanna species by reverse phase HPLC (2008)
• Formation of Agrobacterium rhizogenes –Mediated Transformed Hairy Root Cultures in Gentiana cruciata L. and Comparision of Their Secondary Metabolite Contents (2008)
• Rubia tinctorum L. Bitkisinde Kallus ve Hücre Kültürlerinin Antrakinon Üretim Potansiyellerinin İncelenmesi (2008)
• Secondary metabolites of Centaurea cyanus L (2008)
• Antimicrobial and Cytotoxic Activities of Zingiber officinalis Extracts (2008)
• Bitki Hücre Kültürü Uygulamaları. (2006)
• Biomimetic peptide-conjugated membranes for developing an artificial cornea

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