Hilmi ORHAN
Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Anabilim Dalı
Research areas: Health Sciences, Pharmacology and Therapeutics, Professional Sciences, Pharmaceutical Toxicology, Natural Sciences, Life Sciences, Cytogenetic, Molecular Biology and Genetics, Chemistry, Basic Pharmaceutics Sciences
Publications
- Potential Proteasome-Inhibitory Effects of Commonly Used Drugs: An In Vitro Repurposing Study (2026)
- Tissue Levels of Persistent Organic Pollutants and Biotransformation Enzyme Polymorphisms in Human Stomach Cancer (2026)
- Dose- and Organ-Specific Dual Effects of MitoTempo in Paracetamol-Induced Hepatorenal Toxicity in Mice (2026)
- The Possible Role of Mitochondrial ATM, CDK-1, and RAN Expression in the Radioresistance of Human Lung Adenocarcinoma A549 Cells (2026)
- Tissue levels of persistent organic pollutants and biotransformation enzyme polymorphisms in human stomach cancer (2026)
- Environmental pollutants and genetic toxicity: From mechanisms to human studies (2025)
- Vemurafenib based hydrogels as potential topical bioformulations for the treatment of melanoma (2025)
- Silybin, silychristin and silydianin are potential novel plant-based Pannexin1 channel inhibitors (2025)
- Differential Mitochondrial Responses of Non-Cancerous and Cancerous Lung Cell Lines to a Single Dose of Ionizing Radiation (2025)
- P18-79 Synthesis and Evaluation of Novel Polyamine Transporter-Targeted Conjugates in Wild-Type and Mutant CHO Cells (2025)
- Blood and tissue levels of persistent organic pollutants and genetic susceptibility in patients with breast cancer (2024)
- The cytotoxic, genotoxic and mitotoxic adverse outcomes of atractylis gummifera extract in vitro (2024)
- Review of: "A Review of the Scientific Literature on Experimental Toxicity Studies of COVID-19 Vaccines, with Special Attention to Publications in Specific Toxicology Journals" (2024)
- Immunomodulatory Effects of MDA-MB-231-derived Exosome Mimetic Nanovesicles on CD4+ T Cell Line (2024)
- The role of tissue persistent organic pollutants and genetic polymorphisms in patients with benign and malignant kidney tumors (2024)
- Development, Characterization, and Evaluation of Potential Systemic Toxicity of a Novel Oral Melatonin Formulation (2024)
- Blood and tissue levels of persistent organic pollutants and genetic susceptibility in patients with breast cancer (2024)
- The role of tissue persistent organic pollutants and genetic polymorphisms in patients with benign and malignant kidney tumors (2024)
- P12-23 Comparative mitochondrial changes in Paracetamol-induced kidney and liver toxicity in mice (2024)
- Cellular In Vitro Systems to Predict Chemically Induced Adverse Reactions in Humans (2023)
- Role of Oxidative Stress and Reactive Metabolites in Cytotoxicity & Mitotoxicity of Clozapine, Diclofenac and Nifedipine in CHO-K1 Cells In Vitro (2023)
- S07-02: Comparative Mitochondrial and Nuclear DNA Damage by Paracetamol and Other Xenobiotics (2023)
- P18-03: In vivo and In vitro Assessment of Mitochondrial Alterations in Paracetamol-Induced Kidney Injury (2023)
- Mitochondrial versus microsomal bioactivation of paracetamol by human liver and kidney tissues (2022)
- Metabolism and Biotransformation of Xenobiotics (2021)
- Toxicology of Herbal Medicines (2021)
- COMPARATIVE CYSTEINE S-CONJUGATE ß-LYASE ACTIVITIES OF DIFFERENT ORGANS TOWARDS PARACETAMOL IN MICE (2021)
- Cysteine conjugate of paracetamol serves as substrate for kidney cysteine S-conjugates ß-lyase: implications for drug-induced acute kidney injury (2021)
- Paracetamol-associated adverse reactions in kidney: Different mechanistic pathways compared to liver (2021)
- Mitochondrial Biotransformation of Drugs and other Xenobiotics. (2021)
- Biotransformation of Drugs and other Xenobiotics as Key Modulator of Toxicity (2021)
- Bioactivation of clozapine by mitochondria of the murine heart: Possible cause of cardiotoxicity (2021)
- 4-methylpyrazole protects against acetaminophen-induced acute kidney injury (2020)
- PROTEIN AND DNA DAMAGE IN RELATION TO ENVIRONMENTAL POLLUTANT LEVELS AND GENETIC POLYMORPHISMS IN KIDNEY, STOMACH AND BREAST CANCER PATIENTS (2019)
- Structural and functional alterations of mitochondria in chemically-induced cytotoxicity (2019)
- Immunomodulatory effects of breast cancer-derived exosome mimetic nanovesicles (2019)
- Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study (2019)
- An Expert Roundtable Discussion on Mitochondrial Toxicity (2019)
- Kidney, breast and stomach cancers in relation to internal concentrations of persistent organic pollutants, DNA damage markers and related polymorphisms (2018)
- INVOLVEMENT OF REACTIVE METABOLITES IN CYTOTOXIC EFFECTS OF VARIOUS FREQUENTLY USED DRUGS IN VITRO (2018)
- Stability of mitochondrial intactness for further toxicological studies (2018)
- Ege Üniversitesi Eczacılık Fakültesi Eğitim Programı İyileştirme ve Geliştirme Projesi Kapsamında Yapılan Eczacılık Mesleği Görev Analizi Çalışması (2018)
- Ege Üniversitesi Eczacılık Fakültesi Lisans Eğitimi Programı’nın EczÇEP’le ve Ulusal Standartlarla Uyumunu Geliştirme, Öğretim ve Değerlendirme Süreçlerini İyileştirme Projesi (2018)
- Investigation of Mitochondrial Respiration Dysfunction Caused by Some Drugs (2018)
- Inter-individual and inter-organ variability in the bioactivation of paracetamol by human liver and kidney tissues (2018)
- Bir zincir market firmasının tüketici ürünleri için insan sağlığı toksikolojik risk değerlendirmesi raporu Kırtasiye Ürünleri, Okul Malzemeleri, Çocuk Tekstil Ürünleri ve Ayakkabılarda: Toksik Elementler, Kadmiyum, Nikel, Organik kalay, Azo-boyar Madde ve Aromatik Aminler, Toplam Fitalat, Bisfenol A, Alkilfenoksietoksilatlar (APEO), Uçucu Organik Bileşikler (VOC) (2017)
- Total Estrogenic Activity of Adipose Tissue as Biomarker of Exposure to Endocrine Disruptors in Humans (2017)
- Oxidative DNA damage in cancer patients: Associations between persistent organic pollutants and biomarkers of cellular targets (2017)
- Measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in urine by an improved ELISA (2017)
- Oxidative DNA Damage in cancer patients: Associations between persistent organic pollutants and biomarkers of cellular targets (2017)
- Total estrogenic activity of adipose tissue as biomarker of exposure to persistent organic pollutants in humans (2017)
- Non-animal Approaches in Safety Testing (2017)
- Measurement of 8-oxo-7,8-dihydro-2-deoxyguanosine in urine by an improved ELISA (2017)
- Güvenlilik Testlerinde Hayvan-dışı Yaklaşımlar (2017)
- Periodic monitoring of persistent organic pollutantsand molecular damage in Cyprinus carpio from Büyük MenderesRiver (2017)
- Bir zincir market firmasının tüketici ürünleri için insan sağlığı toksikolojik risk değerlendirmesi raporu Kırtasiye Ürünleri ve Okul Malzemelerinde: Toksik Elementler, Azo-boyar Madde ve Aromatik Aminler, Toplam Fitalat, Uçucu Organik Bileşikler (VOC) (2016)
- Development of biomarkers to assess individual exposure to traffic related air pollution (2016)
- Urinary 8-oxo-7,8-dihydro-2 '-deoxyguanosine analysis by an improved ELISA: An inter-laboratory comparison study (2016)
- Contribution of reactive metabolites to cytotoxicity of various drugs in vitro: The role of CYP enzymes and metal contamination (2016)
- Synthesis and in vitro antioxidant activity studies of melatonin analogue compounds (2016)
- In vitro and in silico evaluation of aromatase inhibitory activity of apigenin and amentoflavone; dual benefit of St. John's Wort in postmenopausal women (2016)
- Design, synthesis and investigation of dual benefits of 2-methyl indole derivatives in hormone-dependent breast cancer: Aromatase inhibitory and antioxidant activity (2016)
- Biotransformation of clozapine by microsomaland mitochondrial fractions of mouse liver andheart Organ specific bioactivation as a possiblecause of cardiotoxicity (2016)
- Introduction/Chair (2016)
- Mitochondrial Bioactivation Possible Cause of Drug Induced Toxicities (2016)
- Biotransformation of clozapine by microsomal and mitochondrial fractions of animal liver and heart: organ-specific bioactivation as a possible cause of cardiotoxicity (2016)
- Contribution of reactive metabolites to cytotoxicity of various drugs in vitro The role of CYP enzymes and metal contamination (2016)
- Involvement of mitochondria in drug-induced toxicities (2016)
- Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine analysis by an improved ELISA: An inter-laboratory comparison study (2016)
- Toxicology as an academic discipline in European Universities (2016)
- Metal pollution in biotic and abiotic samples of the Büyük Menderes River, Turkey (2016)
- Screening of Reactive Metabolite Formation from Drugs Drug Candidates as a Possible Cause of Adverse Reactions (2015)
- Rosiglitazone biotransformation in vitro: Enzyme from different sources and rat organs, and the effect of various glutathione S-transferases in electrophilic intermediate conjugation. (2015)
- LC TANDEM MS BASED ASSESSMENT OF ACETAMINOPHEN IN HUMAN LIVER AND KIDNEY NAPQI FORMATION AND CYP ACTIVITIES (2015)
- Contribution of reactive metabolites to mıtochondrial damage in CHO-K1 cells exposed to various drugs (2015)
- Mitochondria in adverse drug reactions (2015)
- ROSIGLITAZONE BIOTRANSFORMATION IN VITRO ENZYMES FROM DIFFERENT SOURCES AND THE EFFECT OF VARIOUS GLUTATHIONE S TRANSFERASES IN ELECTROPHILIC INTERMEDIATE CONJUGATION (2015)
- Metal pollution in biotic and abiotic samples of the Büyük Menderes River (2015)
- Contribution of reactive metabolites to mitochondrial damage in CHO K1 cells exposed to various drugs (2015)
- Periodic Monitoring of Persistent Organic Pollutants and Molecular Damages of Cyprinus carpio from Büyük Menderes River (2015)
- Periodic monitoring of persistent organic pollutants and molecular damage in Cyprinus carpio from Büyük Menderes River (2015)
- Extrahepatic targets and cellular reactivity of drug metabolites. (2015)
- Exposure, internal dose analysis and adverse outcomes of environmental pollutants in humans (2014)
- Türk Toksikoloji Derneği ve Adli Toksikoloji (2014)
- İnsan Karaciğer ve Böbrek Dokusunda Bireysel Parasetamol Biyoaktivasyon Kapasitesi Farklılığı: Reaktif Metabolit Oluşumu, CYP2E1 ve CYP3A4 Aktivitesi Belirlenmesinde LC-MS/MS Uygulaması (2014)
- Extrahepatic Targets and Cellular Reactivity of Drug Metabolites (2014)
- Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio (2014)
- Editorial (Thematic Issue: Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions) (2014)
- Cofactor metals and antioxidant enzymes in cisplatin-treated rats: effect of antioxidant intervention (2014)
- Environmental and biological monitoring of persistent organic pollutants in waterbirds by non-invasive versus invasive sampling (2014)
- INTERINDIVIDUAL VARIABILITY IN GENERATING ACETAMINOPHEN REACTIVE METABOLITE NAPQI BY VARIOUS HUMAN LIVER AND KIDNEY MICROSOMES (2013)
- Cocuklarda Kimyasal Maddelere İlişkin Farkındalığın Artırılması: Bir Öğretim Materyalinin Geliştirilmesi ve Denenmesi. (2013)
- Target organs and cellular reactivity of drug metabolites (2013)
- Nanotoxicology (2013)
- Target Organs and Cellular Reactivity of Drug Metabolites (2013)
- Türkiye’de preklinik ilaç geliştirme çalışmaları ve toksikolojinin rolü (2013)
- Interference of Metals and Medications with the Detection of Lipid Peroxidation in Humans by Photometric TBARS Assay (2013)
- Raising the awareness on chemicals in children Developing and piloting of a teaching material (2013)
- Persistent Organic Pollutants POPs and Toxicological Responses in Gray Mullet and Seabass from Büyük Menderes River Estuary and Vicinity. Congress Abstract Book s 36 (2012)
- İşçi biyolojik örneğinde pestisit analizi. Nörolojik hastalığı olan bir işçinin kan ve adipöz dokusunda pestisit düzeylerinin analizi (2012)