Hande GÜRER ORHAN
Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Anabilim Dalı
Research areas: Health Sciences, Pharmacology and Therapeutics, Professional Sciences, Pharmaceutical Toxicology, Natural Sciences, Life Sciences, Basic Pharmaceutics Sciences, Chemistry, Cytogenetic, Molecular Biology and Genetics
Publications
- Endocrine and metabolism modulating effects of paracetamol: From in vitro signaling to in vivo metabolic reprogramming in male mice (2026)
- Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice (2026)
- Beneficial effects of an indole derivative melatonin analogue in estrogen receptor positive breast cancer (2026)
- Novel 3,3′-diindolylmethane derivatives as multi-pathway modulators: targeting estrogen-dependent and independent breast cancer carcinogenesis (2026)
- MULTI-TARGETED EFFECTS OF NOVEL MELATONIN ANALOGUES: AROMATASE INHIBITION, ER ANTAGONISM AND CYP1 INHIBITORY ACTIVITY (2026)
- The effects of citalopram and sertraline on adipogenesis and lipogenesis in 3T3-L1 cells (2025)
- Novel sulfonamide-based compounds as dual inhibitors of hCYP1B1 and hCYP19A1 with anticancer activity against breast cancer cells (2025)
- P31-26 Investigation of citalopram-induced adipogenesis and lipogenesis in 3T3-L1 cells (2025)
- P18-99 Multi-Targeted Effects of Newly Synthesized Melatonin Analogues: Aromatase Inhibition, ER Antagonism, and CYP1 Inhibitory Activity (2025)
- Olası Advers Etki Mekanizması Olarak İlaçlarla Adipojenez ve Lipojenezin Modülasyonu (2024)
- Antidepressant induced phospholipidosis and lysosomal dysgenesis during <i>in vitro</i> adipogenesis (2024)
- Modulation of adipogenesis and lipogenesis by indomethacin and pantoprazole (2024)
- In Vitro Evaluation of Endocrine‐Related Adverse Effects of 5‐Fluoroindole Derived Melatonin Analogues with Antioxidant Activity (2024)
- Design, Synthesis, and Investigation of Anticancer and Antioxidant Potential of Novel Indole‐Based Melatonin Analogues in Breast Cancer (2024)
- Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline (2024)
- The effects of melatonin and its analogues on steroidogenesis pathway: a possible therapeutical or adverse effect. (2023)
- Evaluation of Endocrine Related Adverse Effects of Non-Endocrine Targeted Pharmaceuticals in Cellular Systems (2023)
- Antiproliferative activity of Amaryllidaceae alkaloids from Leucojum aestivum L. of Turkish origin (2023)
- Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin (2023)
- In vitro investigation of potential endocrine disrupting and obesogenic effects of Sertraline and Citalopram (2022)
- Causality Between Prenatal Exposure to Pharmaceuticals and Childhood Obesity (2022)
- Causality Between Prenatal Exposure to Pharmaceuticals and Childhood Obesity (2022)
- Obesogens: Definition, mechanisms of action, potential industrial chemicals and pharmaceuticals (2022)
- Melatonin and redox homeostasis (2022)
- Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer (2021)
- Targeting estrogen related pathways against breast cancer (2021)
- Advantages and Disadvantages of Two In Vitro Assays in Evaluating Aromatase Activity: “A Cell-Based and a Cell-Free Assay” (2021)
- Kimyasal Savaş Toksikolojisi Cilt II: Zehirlenme Yönetimi (2021)
- Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer (2021)
- Overcoming the Restricted Therapy Options and Monitoring Challenges in Metastatic Breast Cancer (2021)
- The Role of Biotransformation in the Activity of Endocrine Disruptors (2021)
- Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin (2021)
- In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone (2021)
- Modulators of Oxidative Stress: Chemical and Pharmacological Aspects (2020)
- Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies (2020)
- Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies (2020)
- Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies (2020)
- New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential (2020)
- Modulators of Oxidative Stress: Chemical and Pharmacological Aspects (2020)
- Nonclinical Evaluation of Endocrine-Related Drug Toxicity (2019)
- Lisansüstü Eğitimde Danışmanlık El Kitabı (2019)
- ANTI-METASTATIC CAPACITIES OF MELATONIN RECEPTOR AGONISTS ON DIFFERENT BREAST CANCER CELL LINES (2019)
- Adjuvant Melatonin Analogs Could Be Beneficial in Triple Negative Breast Cancer Therapy In Vitro (2019)
- Molecular docking and in vitro bioactivity of 5-fluoroindole derivatives on ER, aromatase and CYP1B1 activity in breast cancer cells (2019)
- Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems (2019)
- Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis (2019)
- In Vitro Methods for the Evaluation of Oxidative Stress (2018)
- Synthesis and Antioxidative Evaluation of N-amide SubstituentMelatonin Derivatives (2018)
- Recent Advances in Analytical Techniques (2018)
- Ege Üniversitesi Eczacılık Fakültesi Eğitim Programı İyileştirme ve Geliştirme Projesi Kapsamında Yapılan Eczacılık Mesleği Görev Analizi Çalışması (2018)
- Ege Üniversitesi Eczacılık Fakültesi Lisans Eğitimi Programı’nın EczÇEP’le ve Ulusal Standartlarla Uyumunu Geliştirme, Öğretim ve Değerlendirme Süreçlerini İyileştirme Projesi (2018)
- Lectin attached affinity cryogels for amyloglucosidase adsorption (2018)
- Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies (2018)
- Targets for anticancer drugs in estrogen-induced carcinogenesis (2017)
- Total Estrogenic Activity of Adipose Tissue as Biomarker of Exposure to Endocrine Disruptors in Humans (2017)
- Development of Ketoprofen Solid Dispersions and Evaluation of Their Protective Effects against DNA Damage and Cytotoxicity Potential (2017)
- Total estrogenic activity of adipose tissue as biomarker of exposure to persistent organic pollutants in humans (2017)
- Fluconazole Mucoadhesive In Situ Gel and Oral Strip Formulations: In Vitro Performance (2017)
- Development of Ketoprofen Solid Dispersions and Evaluation of Their Protective Effects against DNA Damage and Cytotoxicity Potential (2017)
- The Role of Oxidative Stress Modulators in Breast Cancer (2017)
- Detection of Reactive Oxygen and Nitrogen Species by Electron Paramagnetic Resonance (EPR) Technique (2017)
- Glifosat ve Kanser Tartışmaları (2017)
- In vitro antioxidant/prooxidant effects of combined use of flavonoids (2017)
- Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis (2016)
- Preparation of Oral Strips Containing Fluconazole for Treatment of Oral Candidiasis (2016)
- Performance of the in vitro assays for testing endocrine disrupters (2016)
- Novel indole-based melatonin analogues: Evaluation of antioxidant activity and protective effect against amyloid β-induced damage (2016)
- Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities (2016)
- Puskullu MO, Shirinzadeh H, Nenni M, Gurer-Orhan H, Suzen S. Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues. (2016)
- Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis (2016)
- Melatonin, its Metabolites and its Synthetic Analogs as Multi-Faceted Compounds: Antioxidant, Prooxidant and Inhibitor of Bioactivation Reactions (2015)
- Improved Treatment of Atopic Dermatitis with Corticosteroid Loaded Liposomes (2015)
- Melatonin its metabolites and its synthetic analogs as multi faceted compounds antioxidant prooxidant and inhibitor of bioactivation reactions (2015)
- Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues (2015)
- Effective topical delivery systems for corticosteroids: dermatological and histological evaluations (2014)
- Corticosteroid Loaded Liposomes For Atopic Dermatitis Treatment (2014)
- Development of fluconazole mucoadhesive nanoparticles for oral candidiasis treatment (2014)
- Melatonin, its Metabolites and its Synthetic Analogs as Multi-Faceted Compounds: Antioxidant, Prooxidant and Inhibitor of Bioactivation Reactions (2014)
- New Antioxidant Drug Development Studies On Neurohormone Melatonin and Synthetic Analogs (2014)
- Cocuklarda Kimyasal Maddelere İlişkin Farkındalığın Artırılması: Bir Öğretim Materyalinin Geliştirilmesi ve Denenmesi. (2013)
- Comparision of antioxidant activities of newly synthesized melatonin analogues (2013)
- Raising the awareness on chemicals in children Developing and piloting of a teaching material (2013)
- Antioxidant activity of indole based melatonin analogues in erythrocytes and their voltammetric characterization (2013)
- Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization (2012)
- Hande Gürer Orhan Yasemin Toker Duysal Uslu Özlem Yılmaz Dilsiz Altuğ Yavaşoğlu Erdal Bedir In vitro and in vivo evaluation of potential endocrine disrupting effects of herbal dietary supplements 8 Uluslararası katılımlı Türk Toksikoloji Derneği Kongresi Antalya 15 18 Kasım 2012 (2012)
- In vitro evaluation of potential endocrine disrupting effects of several herbal dietary supplements (2010)
- Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies (2010)
- Kimyasalların Zararları Konusunda Çocukların Farkındalıklarının Arttırılması Projesi (2009)
- Preventive effect of aminoguanidine compared to vitamin E and C on cisplatin-induced nephrotoxicity in rats (2009)
- Some nonylphenol isomers show antiestrogenic potency in the MVLN cell assay (2009)
- Investigation of biphasic effects of quercetin and genistein in vitro (2008)
- Synthesis and Evaluation of in vitro Antioxidant Capacities of some Benzimidazole Derivatives (2006)
- Screening the oxidative potential of several mono and di halogenated biphenyls and biphenyl ethers in rat hepatocytes (2006)
- Misincorporation of free meta tyrosine into cellular proteins A potential cytotoxic mechanism for oxidised amino acids (2006)
- A cell biochemical induced oxidative stress studies; Application multiparameter biomarker set (2006)
- Induction of oxidative damage by halogenated biphenyls and biphenyl ethers in rat hepatocytes. (2006)
- Preventive effect of aminoguanidine on cisplatin-induced nephrotoxicity in rats—Comparison to Vitamins E and C (2006)
- Screening the oxidative potential of several mono- and di-halogenated Biphenyls and biphenyl ethers in rat hepatocytes (2006)
- Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives. (2006)
- Misincorporation of free m-tyrosine cytotoxic mechanism for oxidized a into cellular proteins: a potential amino acids (2006)