Gülnur SEVİN

Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Anabilim Dalı

Research areas: Health Sciences, Pharmacology and Therapeutics, Pharmacology, Professional Sciences, Medicine, Natural Sciences, Basic Pharmaceutics Sciences, Life Sciences, Fundamental Medical Sciences, Internal Medicine Sciences

Publications

• Osthole improves erectile function by increasing endogenous H2S production (2025)
• Hydrogen sulfide is a key mediator in the antioxidant effects of osthole on mouse corpus cavernosum and liver (2025)
• Isoimperatorin induces relaxation in mice corpus cavernosum via increasing hydrogen sulfide (H2S) synthesis (2025)
• Osthole improves erectile function by increasing endogenous H2S production (2025)
• EXPOSURE TO MONOSODIUM GLUTAMATE IMPAIRS MURINE ERECTILE TISSUE FUNCTION (2025)
• Exploring the role of osthole in preventing vascular dysfunction in high-glucose environments (2024)
• H2S is a key mediator in the vascular protective effects of osthole against oxidative stress (2024)
• Hydrogen sulfide is a key mediator in the antioxidant effects of osthole on mouse corpus cavernosum and liver (2024)
• Isoimperatorin induces relaxation in mice corpus cavernosum via increasing hydrogen sulfide (H2S) synthesis (2024)
• H2S is involved in the relaxant effects of osthole on murine corpus cavernosum (2024)
• The Impact of Empagliflozin in Diabetic Erectile Dysfunction: H₂S-Mediated Benefits (2024)
• Effects of Osthole on Early Brain Injury and Cerebral Vasospasm in an Experimental Subarachnoid Hemorrhage Model (2024)
• Chemotherapy-Induced Nausea and Vomiting (2023)
• EMPAGLIFLOZIN EXERTS H2S-MEDIATED VASCULAR BENEFICIAL EFFECTS IN DIABETIC ERECTILE DYSFUNCTION (2023)
• A new insight into the hepatoprotective effect of sildenafil: The role of H2S (2023)
• PHARMACOLOGY AND TOXICOLOGY OF CANNABINOIDS (2023)
• The natural coumarin osthole improves erectile function by increasing H2S synthesis (2023)
• The Effects of Novel Triazolopyrimidine Derivatives on H2S Production in Lung and Vascular Tonus in Aorta (2023)
• N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity (2023)
• A new insight into the hepatoprotective effect of sildenafil: The role of H2S (2023)
• G-Protein Kenetli Reseptör Kinaz-2 (2023)
• PRANGOS HEYNIAE RELAXES MURINE PENILE TISSUE VIA INCREASING NO AND H2S SYNTHESIS (2022)
• THE RELAXANT MECHANISMS OF PRANGOS UECHTRITZII ROOTS IN MOUSE CORPUS CAVERNOSUM (2022)
• Investigation of the role of H2S in the hepatoprotective effects of sildenafil and osthole (2022)
• The effects of monosodium glutamate added to foods as a taste enhancer on erectile function (2022)
• Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum (2022)
• H2S releasing sodium sulfide protects against pulmonary hypertension by improving vascular responses in monocrotaline-induced pulmonary hypertension (2022)
• N‐Substituted piperidine‐3‐carbohydrazide‐hydrazones against Alzheimers disease: Synthesis and evaluation of cholinesterase, beta‐amyloid inhibitory activity, and antioxidant capacity (2022)
• Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs (2022)
• Medisinal Kimya Giriş (2021)
• İlaç hedefi olarak nükleik asitler (2021)
• INVESTIGATION OF THE ROLE OF HYDROGEN SULFIDE IN THE VASCULAR RELAXING EFFECT OF OSTHOLE (2021)
• Taurine supplementation protects lens against glutathione depletion (2021)
• DOES HYDROGEN SULFIDE CONTRIBUTE TO THE EFFECT OF OSTHOLE ON ERECTILE FUNCTION? (2021)
• Comparative evaluation of relaxant effects of three prangos species on mouse corpus cavernosum: Chemical characterization and the relaxant mechanisms of action of P. pabularia and (+)-oxypeucedanin (2021)
• Taurine supplementation protects lens against glutathione depletion (2021)
• Hydrogen sulfide-targeted molecules may be new therapeutic targets for pulmonary arterial hypertension. (2020)
• The journey from ethnobotanical studies to pharmacological target: The effect of imperatorin and isoimperatorin on penile relaxation. (2020)
• Fare Penil Dokusunda Gevşetici Etki Gösteren Endemik Bir Bitki: Prangos uechtritzii BOISSHAUSSKN (2019)
• Fare Penil Dokusunda Gevşetici Etki Gösteren Endemik Bir Bitki: Prangos uechtritzii BOISSHAUSSKN (2019)
• 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor induces H2S formation. (2019)
• 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor induces H2S formation (2019)
• Tracking the Oxypeucedanin: from ethnobotanical studies to pharmacological target (2019)
• Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation (2018)
• Investigation of changes in vWF expression in rabbit carotid artery collar model (2018)
• The Effect of Prangos pabularia Lindl. on erectile dysfunction associated with H2S (2018)
• Effects of Prangos heyniae H.Duman&M.F.Watson Roots on Erectile Function (2018)
• Türk Farmakopesi 2017 (2018)
• Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro/ex vivo/in vivo evaluation (2018)
• FLUVASTATİNİN TAVŞAN KAROTİD ARTERİ YAKA MODELİNDE İNTİMAL KALINLAŞMA ÜZERİNE ETKİLERİ (2018)
• Investigation of changes in vWF expression in rabbit carotid artery collar model (2018)
• Effects of prangos uechtritzii BoissHausskn roots on erectile disfunction (2018)
• EFFECT of THE TRIAZOLOPYRIMIDINE COMPOUND on ENDOGENOUS H2S LEVELS in LUNG TISSUE HOMOGENATES:A SCAFFOLD HOPPING APPLICATION on RESVERATROL DERIVATIVES (2018)
• EFFECTS OF PRANGOS UECHTRITZII BOISSHAUSSKN ROOTS ON ERECTILE DISFUNCTION (2018)
• A NEW MULTITARGETED DRUG CANDIDATE IN ALZHEIMER DISEASE: 1,4-DIHYDROPYRIDINE-BENZYLIDENHYDRAZON DERIVED AChE INHIBITOR (2018)
• Prangos pabularia Lindl. erektil disfonksiyon için çözüm olabilir mi? (2018)
• A new multitargeted drug candidate in Alzheimer disease: 1,4-dihydropyridine-benzylidenhydrazon derived AChE inhibitor (2018)
• . Effect of the triazolopyrimidine compound on endogenous H2S levels in lung tissue homogenates: A scaffold hopping application on resveratrol derıvatıves. (2018)
• Effects of Prangos heyniae H.DumanM.F.Watson Roots on Erectile Function (2018)
• Hydrogen sulfide: a candidate multitarget ligand for cardiovascular diseases (2018)
• Responsibility for Rational Drug Use: Role of Pharmacists (2017)
• Goodman ve Gilman'ın Farmakoloji ve Tedavi El Kitabı (2017)
• Yeni sentezlenen resveratrol türevleri fare aortasında gevşemeye ve hidrojen sülfit oluşumuna neden olurlar (2017)
• Resveratrol analog induces hydrogen sulfide formation and vasorelaxation (2017)
• ALZHEİMER TEDAVİSİNDE ÇOK HEDEFLİ BİR İLAÇ ADAYI: 1,4-DİHİDROPİRİDİN-BENZİLİDENHİDRAZON TÜREVİ ASETİLKOLİN ESTERAZ İNHİBİTÖRÜ (2017)
• Resveratrol enhances endogenous H2S dependent relaxation in vascular tissues (2016)
• Role of MMP2 on vascular reactivity changes in early atherosclerosis (2016)
• Ege Üniversitesi Eczacılık Fakültesi Staj Uygulamaları (2016)
• L cysteine Hydrogen sulfide pathway is impaired under oxidative stress in mice aorta (2016)
• Effects of taurine in a model of oxidative stress induced by gluthation depletion in rabbit carotid arteries (2016)
• A new mechanism for beneficial effect of resveratrol Hydrogen sulfide H2S formation (2016)
• Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits. (2016)
• New drug candidates targeting hydrogen sulfide Poly Pharmacology expanding paul Ehrlich s magic bullet concept (2016)
• Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits (2016)
• Hydrogen sulfide: A novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta (2016)
• Role of Six Trans Membrane Protein of Prostate STAMP Proteins in Prostate Cancer Relation with Survival Genes (2016)
• The role of Six Trans membrane protein of prostate STAMP Proteins in prostate cancer Relation with survival genes (2016)
• Resveratrol Stimulates Hydrogen Sulfide (H2S) Formation to Relax Murine Corpus Cavernosum (2015)
• In vitro evaluation of intravesical gel formulations of gemcitabine HCL loaded nanoparticles on bladder cancer cell lines (2015)
• Körfezden Dünyaya Açılan Genç Kapılar Konu TÜBİTAK Burs Programı Programı hazırlayıp sunan Oğuz AKÇORA TRT Kent Radyo İzmir 22 Mart 2015 (2015)
• Hydrogen sulfide is involved in the antioxidant effects of taurine (2015)
• Cytotoxic effects of gemsitabine HCL loaded microspheres and nanoparticles on bladder cancer cell lines (2015)
• Resveratrol nitrik oksitten bağımsız şekilde endojen Hidrojen sülfür yapımını uyarır (2015)
• hydrogen sulfide nitric oxide relation in erectile function (2015)
• Taurinin vasküler tonus regülasyonu ve vasküler oksidatif stres üzerindeki yararlı etkileri için yeni bir mekanizma Hidrojen sülfür (2015)
• Effects of vitamin C treatment on collar-induced intimal thickening (2015)
• Cytotoxic effects of gemcitabine HCl loaded microspheres and nanoparticles on bladder cancer cell lines (2015)
• Antitumor activity of gels containing gemsitabine HCL loaded microspheres and nanoparticles on bladder cancer cell lines (2015)
• The role of hydrogen sulfide on the regulation of vascular tonus in mice aorta and relation with taurine (2015)
• Antitumor activity of gels containing gemcitabine HCl loaded microspheres and nanoparticles on bladder cancer cell lines (2015)
• Öğrenci işleri Programı Konu Avrupa Projelerine Erasmus Comenius katılım kazanımlar ve öğrencilere öneriler programı hazırlayıp sunan Dorukhan YILMAZ TRT 1 Radyosu İzmir 22 Nisan 2015 (2015)
• THE EFFECTS OF RALOXIFENE ON OSTEOCALCIN, AS A BONE TURNOVER MARKER IN ORCHIECTOMIZED RATS (2014)
• Analysis of tumor necrosis factor ?-induced and nuclear factor ?B-silenced LNCaP prostate cancer cells by RT-qPCR. (2014)
• Hiperkolesterolemiye bağlı erektil disfonksiyonda hsp90 aracılı eNOS kaynaklı gevşemeler azalmıştır (2013)
• Functional significance of hsp90-eNOS interaction in penile tissues (2013)
• Different Responses of RT‐PCR Amplifications after Tumor Necrosis alpha (TNFa) Induction at Nuclear Factor kappa B (NFkB) Gene Silenced LNCaP Cells (2013)
• Decreased eNOS relaxations and relation with hsp90 in hypercholesterolemic rabbit aorta (2013)
• Functional significance of hsp90‐eNOS interaction in penile tissues (2013)
• Different Responses of RT-PCR Amplifications after Tumor Necrosis alpha (TNFa) Induction at Nuclear Factor kappa B (NFkB) Gene Silenced LNCaP Cells (2013)
• P10 New mechanism for the beneficial effect of sildenafil on erectile function: H2S (2013)

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