Gönen ÖZŞARLAK SÖZER

Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Anabilim Dalı

Research areas: Health Sciences, Pharmacology and Therapeutics, Pharmacology, Professional Sciences, Natural Sciences, Medicine, Life Sciences, Basic Pharmaceutics Sciences, Fundamental Medical Sciences, Molecular Biology and Genetics

Publications

• Unique liquid crystal-based biosensor for label-free detection of Amyloid beta-42 peptide using gelsolin protein (2026)
• Sirtuin 1 (SIRT1)’in Sinyal Ağlarının Kardiyovasküler Hastalıklar Üzerindeki Etkisi (2026)
• The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective (2026)
• Comparative Effects of Heart Failure Medications on Cardiac Remodeling via the Hydrogen Sulfide (H2S) Pathway: A Systematic Review (2026)
• EMPAGLIFLOZIN EXERTS ITS EFFECTS TARGETING ER STRESS IN DIABETIC CARDIOMYOPATHY: IS THERE A ROLE FOR SIRT1? (2025)
• EFFECT OF SGLT2i ON HEART TISSUE IN DIABETIC RATS: SIRT1 CONNECTION (2024)
• Antioxidant effect of empagliflozin in diabetic rats (2024)
• Relationship of H2S Responses with the Heme Oxygenase Pathway in Mouse Corpus Cavernosum (2024)
• Empagliflozin exerts NO-mediated vascular beneficial effects in diabetic rats (2024)
• Effect of SGLT2i on heart tissue in diabetic rats: SIRT1 connection (2024)
• The Impact of Empagliflozin in Diabetic Erectile Dysfunction: H₂S-Mediated Benefits (2024)
• İNFLAMATUVAR BAĞIRSAK HASTALIKLARI TEDAVİSİNDE KULLANILAN İLAÇLAR (2024)
• EMPAGLIFLOZIN EXERTS H2S-MEDIATED VASCULAR BENEFICIAL EFFECTS IN DIABETIC ERECTILE DYSFUNCTION (2023)
• İmmun Mechanisms (2023)
• DİYABETIK RATLARDA SGLT2i'NİN ANTİOKSİDAN ETKİSİ: GLUKOZÜRİKTEN FAZLASI (2023)
• DİYABETIK RATLARDA SGLT2i'NİN KALP DOKUSUNA ETKİSİ: GİZEM ÇÖZÜLDÜ MÜ? (2023)
• İlaç hedefi olarak nükleik asitler (2021)
• İlacın Piyasaya Sürülmesi (2021)
• Taurine supplementation protects lens against glutathione depletion (2021)
• Fare aortasinda karbon monoksit aracılı vasküler yanıtlar ve diğer gazotransmiterler ile ilişkisi (2021)
• Korunmuş ejeksiyon fraksiyonlu koroner arter hastalığı olan hastaların sağ atriyum dokularında pro matriks metalloproteinaz-2 (MMP-2) enzim aktivitesinin rolü (2021)
• Development of liquid crystal biosensor for the detection of amyloid beta-42 levels associated with Alzheimer's disease (2021)
• Taurine supplementation protects lens against glutathione depletion (2021)
• Optical evaluation of immunocomplex of liquid crystal bound amyloid beta-42 levels associated with Alzheimer's disease (2020)
• Effects of Metformin on vascular reactivity in Streptozotocin-induced diabetic rats (2020)
• Effect of CORM-2 Molecule on Vascular Tonus in Penile Tissue (2020)
• Covid-19 ve Proflaksi (2020)
• The effect of CORM-2 molecule on hydrogen peroxide-induced neuroblastoma cells (2019)
• Ege Üniversitesi Eczacılık Fakültesi Eğitim Programı İyileştirme ve Geliştirme Projesi Kapsamında Yapılan Eczacılık Mesleği Görev Analizi Çalışması (2018)
• Ege Üniversitesi Eczacılık Fakültesi Lisans Eğitimi Programı’nın EczÇEP’le ve Ulusal Standartlarla Uyumunu Geliştirme, Öğretim ve Değerlendirme Süreçlerini İyileştirme Projesi (2018)
• genel anestezikler ve terapotik gazlar (2017)
• Critical time point for apoptotic cell death in an experimental ischemia/reperfusion model and the effect of N-acetylcystein (2017)
• Effects of taurine in a model of oxidative stress induced by gluthation depletion in rabbit carotid arteries (2016)
• Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits. (2016)
• Diverse effects of taurine on vascular response and inflammation in GSH depletion model in rabbits (2016)
• Statin as an Hsp90 activator in the regulation of NOS in vascular dysfunction (2015)
• Telomer Regülasyonu ve Yaşlanma Sürecinde miRNA lar (2015)
• Hiperkolesterolemiye bağlı erektil disfonksiyonda hsp90 aracılı eNOS kaynaklı gevşemeler azalmıştır (2013)
• Decreased eNOS relaxations and relation with hsp90 in hypercholesterolemic rabbit aorta (2013)
• Fluvastatin hiperkolesterolemik etkiden bağımsız şekilde erektil disfonksiyon tedavisinde yararlı olabilir (2013)
• Functional significance of hsp90‐eNOS interaction in penile tissues (2013)
• Experimental Ischemia/Reperfusion Model in Relation to Apototic Cell Death (2013)
• Decreased eNOS relaxations and relation with hsp90 in hypercholesterolemic rabbit aorta (2013)
• Functional significance of hsp90-eNOS interaction in penile tissues (2013)
• Experimental Ischemia Reperfusion Model in Relation to Apototic Cell Death (2013)
• Glutatyon Tüketimi İle Oluşturulan İn vivo Oksidan Stresin Langendorff Perfüze Sıçan Kalbinde Fonksiyonel Parametreler Üzerine Etkisi (2013)
• Aortanın endotelyal disfonksiyonunda fluvastatin tedavisi ve hsp90 ın rolü (2013)
• Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart (2013)
• Hsp90 directed regulation of erectile function and comparison in rabbit vs Mouse (2012)
• Hsp90 directed regulation of erectile function and comparison in rabbit vs mice (2012)
• Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery (2012)
• Hiperkolesteroleminin Tavşan Aortasında Bazal ve Uyarılmış EDRF Yanıtı Üzerine Etkisi (2011)
• Oksidatif Stres Altındaki Kalpte Taurinin Jelatinazlar Üzerindeki Düzenleyici Rolü (2011)
• Penil Dokuda Nitrik Oksit NO Yolağını Kontrol Eden Yeni Bir Protein Protein Etkileşimi Hsp 90 eNOS ve Fizyolojik Önemi (2011)
• Hiperkolesterolemiye bağlı erektil disfonksiyonda EDHF ve EDRF’nin rolü (2011)
• Hiperkolesterolemiye Bağlı Erektil Disfonksiyonda EDHF ve EDRF nin Rolü (2011)
• Endothelin Receptor-Independent Correlation Between HSP47 and Collagen in Rabbit Model of Early Atherosclerosis (2011)
• Taurine suppresses oxidative stress‐potentiated expression of lectin‐like oxidized low‐density lipoprotein receptor and restenosis in balloon‐injured rabbit iliac artery (2011)
• Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty (2010)
• Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events (2010)
• Glutathione Depletion by Buthionine Sulfoximine Induces Oxidative Damage to DNA in Organs of Rabbits in Vivo (2009)
• Tavşanlarda Balon Hasarı Sonrası Damar Düz Kas Hücrelerinde Telomer Devamlılığı ve Oksidan Stresin Rolü (2009)
• MMP-2 and MMP-9 Alteration in Response to Collaring in Rabbits: The Effects of Endothelin Receptor Antagonism (2009)
• Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits (2009)
• Telomere Length Regulation of Vascular Smooth Muscle Cells in a Balloon Injury Model Effects of Oxidative Stress (2008)
• The Role of Oxidative Stress in Hyperplasia Modulation of LOX 1 Expression by Taurine (2008)
• Local Atherosclerotic Plaque Osteopontin is a Prognostic Biomarker for Adverse Cardiovascular Events in Heart Brain and Periphery ESC European Society of Cardiology Congress 30 Ağustos 3 Eylül 2008 Münih Almanya European Heart Journal 2008 29 Abstract Supplement 276 277 (2008)
• Human Plaque Osteopontin Levels Are Associated With Intra plaque Hemorhages in Human Carotid Plaques (2008)
• Oksidatif Stres Varlığında İzole Tavşan Damarlarında Kontraktil Aktivitenin Taurin ile Düzenlenmesi (2007)
• Tavşanlarda Glutatyon Sentez İnhibisyonu Sonucu Oluşan Reaktif oksijen Türleri ve Kan Basıncı Üzerine Taurinin Etkileri (2007)
• Oksidatif Stres Varlığında İzole Tavşan Damarlarında Endotel Kaynaklı Gevşeme Yanıtlarının Taurin ile Düzenlenmesi (2007)
• Oksidatif Stres Varlığında Balon Hasarı Oluşturulan Tavşanlarda Taurinin İntimal Hiperplazi Üzerine Etkileri (2007)
• Oksidatif Stres Varlığında Balon Hasarı Oluşturulan Tavşanlarda Taurinin LOX 1 Ekspresyonu Üzerine Etkileri (2007)
• THP 1 hücrelerde toll benzeri reseptörler ve TGFbeta yolakları arasındaki çapraz ilişki ve osteopontinin rolü (2007)
• Effects of Fluvastatin on H2O2 induced Oxidative Stress in carotid Arteries of Rabbit (2006)
• Cathepsin K and survivin in a collar induced early atherosclerosis model (2006)
• The Role of COX Inhibition in Vascular Reactivity Responses in Rabbit Carotid Artery (2006)
• The effects of chronic ETA ETB receptor blockade in the isolated rabbit aorta (2006)
• Different contractile responses of carotid artery and thoracic aorta in rabbits: tavşanlarda karotid arter ve torasik aortanın farklı kasılma yanıtları (2005)
• HSP 47 and collagen turnover in intimal thickening Role of Endothelin Antagonism (2005)
• Telomere length regulation in the proliferation of vascular smooth muscle cells (2005)
• Erken ateroskleroz modelinde kollajen ve HSP47 Endotelin reseptör antagonizmasının rolü (2005)
• The role of endothelin receptor antagonism in collar-induced intimal thickening and vascular reactivity changes in rabbits (2005)
• Different contractile responses of carotid artery and thoracic aorta in the rabbits. (2005)
• Different contractile responses of carotid artery and thoracic aorta in rabbits Ankara Üniversitesi Eczacılık Fakültesi Dergisi 34 1 27 39 2005 (2005)
• Collar induced changes in matrix melalloproteinase 2 and 9 activities in the rabbit carotid artery and the effect of endothelin antagonism (2004)
• The role of endothelin receptor antagonism in collar induced intimal thickening and vascular reactivity changes in rabbits (2003)
• The role of Matrix Metalloproteinases in collar induced intimal thickening in rabbits (2003)
• Collar induced increase in endothelin levels in the rabbit carotid artery (2003)
• İzole tavşan damarlarında nitrik oksit sentez inhibisyonunun asetilkolin gevşemeleri ile potasyun klorür ve fenilefrin kasılmaları üzerine etkisi (2001)
• Effects of N nitro l arginine inhibition on acethylcholine induced relaxations and potassium chloride and phenylephrine induced contractions on rabbit thoracic aorta and carotid artery (2001)

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