Ayfer YALÇIN
Eczacılık Fakültesi, Temel Eczacılık Bölümü, Biyokimya Anabilim Dalı
Research areas: Health Sciences, Natural Sciences, Life Sciences, Pharmacology and Therapeutics, Basic Pharmaceutics Sciences, Neurobiology, Biochemistry, Medicine, Neurochemistry, Molecular Biology and Genetics
Publications
- Neurobehavioral effects of gamma-glutamylcysteine ethyl ester on the rats treated with kainic acid (2026)
- Neurobehavioral effects of gamma-glutamylcysteine ethyl ester on the rats treated with kainic acid (2026)
- Neurobehavioral effects of gamma-glutamylcysteine ethyl ester on the kainic acidrat model of status epilepticus. (2025)
- Potential neuroprotective effects of 2-hydroxypropyl-β cyclodextrin against amyloid β (1-42)-induced neurotoxicity on the rat hippocampus (2024)
- Establishment and Validation of an Automated System for the Antifactor IIa Assay: A Case Study of Potency Assessment of a Pharmaceutical Gel Formulation (2024)
- Altered Levels of Gene Expression of Drug Metabolism Enzymes in Rat Brain Following Kainic Acid Treatment (2023)
- The Effects of Prenatal Stress on Cortical and Hippocampal Gene Expression Profiles of DNA Methyltransferases and Histone Deacetylases in Female Rats (2022)
- Prenatal Dexamethasone Exposure in Male Rats Alters Gene Expression Patterns of Epigenetic Enzymes in Hippocampus and Cortex (2022)
- Targeting PARP-1 as a potential neurotherapeutic strategy (2019)
- Sağlık Bilimleri Lisansüstü Eğitiminde Karma (Harmanlanmış)Öğrenme Ortamında Uygulanan Bilimsel Araştırmanın Temelleri Dersi:Tasarıma Dayalı Araştırmanın I·lk Sonuçları (2018)
- Ege Üniversitesi Eczacılık Fakültesi Lisans Eğitimi Programı’nın EczÇEP’le ve Ulusal Standartlarla Uyumunu Geliştirme, Öğretim ve Değerlendirme Süreçlerini İyileştirme Projesi (2018)
- Ege Üniversitesi Eczacılık Fakültesi Eğitim Programı İyileştirme ve Geliştirme Projesi Kapsamında Yapılan Eczacılık Mesleği Görev Analizi Çalışması (2018)
- Potential protective effects of hydroxypropyl-beta-cyclodextrin on A beta(1-42)-induced neurotoxicity (2018)
- Neuroprotective Effects of Nicotinamide on Glucose Metabolism through PI3K/PKB Pathway in Aß(1-42) Induced Neurodegeneration (2018)
- The Fundamentals of Scientific Research Course in Blended Learning Environment in Post-Graduate Education of Health Sciences: Initial Results of a Design-Based Research (2018)
- cAMP-related molecules in Aß(1-42) induced neurotoxicity. (2018)
- Karaca O., Yilmaz Y., Öcek Z.A., Uysal Toraman A., Akyol A., Yalçin A., et al. The Fundamentals of Scientific Research Course in Blended Learning Environment in Post-Graduate Education of Health Sciences: Initial Results of a Design-Based Research" (2018)
- Sağlık Bilimleri Lisansüstü Eğitiminde Karma (Harmanlanmış) Öğrenme Ortamında Uygulanan Bilimsel Araştırmanın Temelleri Dersi: Tasarıma Dayalı Araştırmanın İlk Sonuçları (2018)
- Development of Ketoprofen Solid Dispersions and Evaluation of Their Protective Effects against DNA Damage and Cytotoxicity Potential (2017)
- Effect of GCEE or GCEE-loaded microspheres administration on the levels of glutathione and thiol redox molecules in rat brain (2017)
- PARP-1 Enzimini Hedefleyen Terapötik Yaklaşımlar (2017)
- Development of Ketoprofen Solid Dispersions and Evaluation of Their Protective Effects against DNA Damage and Cytotoxicity Potential (2017)
- Effects of nicotinamide treatment on mRNA expression of various enzymes involved in NAD(+) metabolism in A beta(1-42) induced neurodegeneration (2016)
- Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)–Induced Toxicity (2016)
- The nitric oxide mediated effects of nebivolol in cardiorenal syndrome (2016)
- Neuroprotection and CNS Delivery of Neuroprotective Agents (2016)
- Neuroprotective effects of nicotinamide against A 1 42 induced in vivo and in vitro neurodegeneration models (2016)
- Effect of mefenamic acid on base excision repair enzymes against D serine induced neurotoxicity (2016)
- Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)–Induced Toxicity (2016)
- Neuroprotective effects of nicotinamide against Aß(1-42) induced in vivo and in vitro neurodegeneration models. (2015)
- Nitric oxide mediated effects of nebivolol in myocardial infarction:the source of nitric oxide (2015)
- Nitric Oxide Mediated Effects of Nebivolol in Myocardial Infarction The Source of Nitric Oxide (2015)
- PI3K Akt FoxO signaling mediated neuroprotective effects of nicotinamide in A 1 42 induced experimental Alzheimer s disease model (2015)
- Nitric oxide mediated effects of nebivolol in myocardial infarction: the source of nitric oxide. (2015)
- Neuroprotective approaches in Alzheimer s Disease models (2015)
- Effect of gamma glutamylcysteinyl ethyl ester on apoptotic miRNA expressions in kainic acid induced excitotoxicity model (2015)
- An in vitro investigation of long term degenerative effects of mechanical trauma on centrol nervous system neurons (2015)
- In Situ Studies of Ketoprofen Solid Dispersions on DNA Damage in Rat Brain (2015)
- STAT-Dependent Upregulation of 12/15-Lipoxygenase Contributes to Neuronal Injury after Stroke (2015)
- Effect of gamma-glutamyl cysteinyl ethyl ester on apoptotic miRNA expressions in kainic acid induced excitotoxicity model (2015)
- Ex vivo protective effects of nicotinamide and 3‐aminobenzamide on rat synaptosomes treated with Aβ(1–42) (2014)
- Effects of multivitamin minerals supplementation on glutathione peroxidase 1 glutathione reductase and glutathione synthetase gene expression in mice (2014)
- Effect of 3 aminobenzamide treatment on the levels of PARP 1 overactivity oxidative stress and apoptosis induced by amyloid beta peptide 1 42 in the rat brain (2014)
- Ex vivo protective effects of nicotinamide and 3‐aminobenzamide on rat synaptosomes treated with Aβ(1–42) (2014)
- Regulator effect of glutamylcysteine ethyl ester on the levels of antioxidant cellular stress response and apoptotic molecules in kainic acid induced excitotoxicity (2013)
- Protective effects of hydroxypropyl cyclodextrin microspheres loaded nasal formulations on amyloid peptide 1 42 induced neurodegeneration (2013)
- D serine karşı mefenamik asitin baz eksizyon tamir enzimleri ve PARP 1 üzerine etkisi (2013)
- Effect of resveratrol against hydrogen peroxide induced oxidative stress in embryonic neural stem cell culture (2013)
- Kainic acid-induced seizure activity alters the mRNA expression and G-protein activation of the opioid/nociceptin receptors in the rat brain cortex (2013)
- 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood–brain barrier (2013)
- Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease (2013)
- Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells. (2013)
- Electrochemical Determination of Glutathione in Plasma at Carbon Nanotubes Based Screen Printed Electrodes (2013)
- Neuroprotective effects of PARP-1 inhibitors on the model of Alzheimer's Disease induced by Aβ(1-42) (2012)
- Resveratrol attenuates oxidative stress in neuronal and glial restricted precursor cells (2012)
- Induction of oxidative stress apoptosis and inflammation in rat brain regions by D serine (2012)
- EGESEM. Üniversitelerin Topluma Hizmet Uygulamalarında Sürekli Eğitim Merkezlerinin Rolü; EGESEM Aktiviteleri (2012)
- Neuroprotection by mefenamic acid against d -serine: Involvement of oxidative stress, inflammation and apoptosis (2012)
- Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus (2012)
- Effect of melatonin co treatment against kainic acid on thiol redox modulator gene expressions in rat hippocampus (2012)
- Effects of non-steroidal antiinflammatory drugs on D-serine-induced oxidative stressin vitro (2012)
- Neuroprotective effects of PARP-1 inhibitors on the model of Alzheimer's Disease induced by Aβ(1-42) (2012)
- Changes in the cannabinoid CB1 receptor expression level and G protein activation in the kainic acid model of epilepsy (2011)
- Potential protective effects of mefenamic acid on inflammation induced by neurodegeneration (2011)
- In vitro and in vivo determination of DNA damage induced by kainic acid using electrochemical assay and agarose gel electrophoresis (2011)
- D-serine treatment induces oxidative stress in rat brain (2011)
- Gamma‐glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood–brain barrier permeability after experimental brain trauma (2011)
- Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in the kainic acid model of epilepsy (2011)
- Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures (2011)
- Potential antiapoptotic activity of mefenamic acid in D serine induced oxidative stress (2010)
- Expressional mRNA levels and G protein activation of opioid system receptors in kainic acid induced neurodegeneration (2010)
- Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus (2010)
- Effect of gamma-glutamylcysteine ethylester on the levels of c-fos mRNA expression, glutathione and reactive oxygen species formation in kainic acid excitotoxicity (2010)
- Potential neuroprotective effect of γ-glutamylcysteine ethyl ester on rat brain against kainic acid-induced excitotoxicity (2010)
- Stroke Risk in Elderly Individuals: Novel Molecules in Stroke and Therapeutical Targets (2009)
- Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells (2009)
- Alterations in the Expression of the Apurinic/Apyrimidinic Endonuclease-1/Redox Factor-1 (APE/Ref-1) and DNA Damage in the Caudal Region of Acute and Chronic Spinal Cord Injured Rats Treated by Embryonic Neural Stem Cells (2009)
- The Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Acid (2009)
- The Levels of Glutathione and Nitrite-Nitrate and the Expression of BCL-2 MRNA in Ovariectomized Rats Treated by Raloxifene Against Kainic Acid (2009)
- Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats (2009)
- Effect of glutamylcysteine ethyl ester on modulation of c fos gene expressions and glutathione levels in kainic acid model of neurodegeneration (2008)
- Alteration on mRNA levels of p53 and caspase 3 activity in rat brains treated by glutamylcysteine ethyl ester against kainic acid (2008)
- Alterations in the expression of the apurinic apyrimidinic endonuclease 1 redox factor 1 APE REF 1 and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embriyonic neural stem cell (2008)
- Modulation of p53 gene expression and caspase-3 activity by gamma-glutamylcysteine ethyl ester in kainic acid model of neurodegeneration (2007)
- The Comparative Effects Of Mefenamic Acid Microsponge Formulations With Different Polymers On The Rat Brain Cortex DNA (2007)
- Alterations in the expression of the apurinic apyrimidinic endonuclease 1 Redox Factor 1 APE Ref 1 and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embriyonic neural stem cell (2007)
- Bcl 2 mRNA and glutathione levels in ovariectomized rat brains treated by raloxifene against kainic acid (2007)
- Modulation of neuroprotective gene expressions and DNA damage by potential antioxidant molecules in animal models of neurodegeneration (2007)
- Elevation of hippocampal glutathione and induction of thiol redox modulator gene expressions by glutamylcysteine ethyl ester against kainic acid induced oxidative stress (2007)
- In vitro release - In vivo microbiological and toxicological studies on ketoconazole lipid granules (2007)
- Modulation of c-fos gene expressions and glutathione levels by gamma-glutamylcysteine ethyl ester in kainic acid model of neurode-generation (2007)
- The potential antioxidant effect of raloxifene treatment: a study on heart, liver and brain cortex of ovariectomized female rats (2007)
- The potential antioxidant effect of raloxifene treatment a study on heart liver and brain cortex of ovariectomized female rats (2007)
- Effect of raloxifene treatment on the level of APE Ref 1 mRNA expression in brain cortex of ovariectomized female rats (2006)
- An in vitro dissolution and biochemical evalution of ketoconazole tablets prepared with Compritol 888 ATO and Compritol HD5 ATO (2006)
- The potential antioxidant effect of raloxifene treatment: a study on heart, liver and brain cortex of ovariectomized female rats (2006)
- Effect of Mefeneamic Acid And Its Microsponges Formulations On The Rat Brain Cortex DNA (2006)
- Effect of melatonin on kainic acid induced DNA damage in rat brain cortex (2006)
- The effect of melatonin on lipid peroxidation and nitrite/nitrate levels, and on superoxide dismutase and catalase activities in kainic acid-induced injury. (2005)
- Raloxifene up-regulates expression of BCL-2 mRNA in ovariectomized rat hippocampus treated by kainic acid (2005)