Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures
Articles > Article · 2011
Authors: Engin BOJNIK, Ezgi Turunc, Güliz ARMAGAN, Lütfiye KANIT, Sandor BENYHE, Ayfer YALÇIN, Anna BORSODI
Epilepsy Research, Journal Indexed in SCI Expanded, International, WoS, 2011, vol 99, pp 64-68
DOI: 10.1016/j.eplepsyres.2011.10.020
Summary
It has been known for centuries that exogenous cannabinoids, such as tetrahydrocannabinol have anticonvulsant activity. Recent studies have advanced our understanding of the endogenous cannabinoid system and renewed the interest in cannabinoids as a potential treatment for epilepsy. The endogenous cannabinoid system is rapidly activated after seizure activity but still little is known about the molecular mechanisms underlying the role of the cannabinoid system in epilepsy.