Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation
Articles > Article · 2016
Authors: Mohammad Hossein GERANMAYEH, Alireza NOURAZARIAN, Çığır BİRAY AVCI, Reza RAHBARGHAZI, Mehdi FARHOUDI
Molecular Neurobiology, Journal Indexed in SCI Expanded, International, WoS, 2016, vol 54, pp 7689-7705
DOI: 10.1007/s12035-016-0286-4
Summary
Establishing systemic therapeutics for neuro-inflammatory diseases is a main objective of regenerative medicine, certainly focusing on restoration of BBB dysfunction and neurovascular reconstitution. In this context, the regenerative capacity and therapeutic effects of different stem cells have been recently found to bring hopeful outcomes through trans-differentiation, paracrine interactions, and molecular cross-talk of transplanted stem cells with resident cells of blood-brain barrier. Here, we highlight some of the most recent scientific breakthroughs and discoveries by different authorities. Potency of different types of stem cells on the regulation and maintenance of endothelial and perivascular cells via various microRNAs was also studied.