Celiac disease in children with Down syndrome: Importance of follow-up and serologic screening
Makaleler > Tam Makale · 2003
Yazarlar: Muhsin Özgür ÇOĞULU, Feriştah Ferda ÖZKINAY, Cumhur GÜNDÜZ, T CANKAYA, S AYDOGDU, F OZGENC, Necil KÜTÜKÇÜLER, C OZKINAY
PEDIATRICS INTERNATIONAL, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2003, cilt 45, ss 395-399
DOI: 10.1046/j.1442-200x.2003.01755.x
Özet
Background : Celiac disease, also known as gluten-sensitive enteropathy, is a chronic inflammation disease of the small intestinal mucosa. Detection of Ig-A antigliadin antibodies (AGA) and antiendomysial antibodies (EMA) in serum is important in the diagnosis and screening for celiac disease. Antiendomysial antibodies have greater sensitivity compared to antigliadin antibodies. It has been reported that the prevalence of celiac disease is higher in children with Down syndrome than the other autoimmune conditions. The aim of the present study was to investigate the incidence of celiac disease in children with Down syndrome, to assess the availability of Ig-A AGA and EMA for serologic screening, and to highlight the importance of follow-up for children with Down syndrome.