Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation
Articles > Article · 2021
Authors: Ugur Avcibasi, Taner Turkyarar, Aysegul Karadag, Buket Bakan, Nefise Ülkü KARABAY YAVAŞOĞLU, KEVSER KUŞAT, Sinan AKGÖL, Derya GÜLCEMAL, Volkan Tekin, Fazilet Zümrüt BİBER MÜFTÜLER, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2021, vol 329, pp 511-525
DOI: 10.1007/s10967-021-07817-6
Summary
The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.