Idiopathic CD4+ T cell lymphocytopenia with the absence of B cells and CD8+28+ cells in peripheral blood.
Makaleler > Tam Makale · 2002
Yazarlar: Necil KÜTÜKÇÜLER, Güzide AKSU, F GENEL, C OZTURK
Clinical and Experimental Medicine, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2002, cilt 2, ss 143-146
Özet
The absence of B cells and a severe decrease in CD8+28+ cells were observed in two female children with CD4+ T cell lymphocytopenia. Idiopathic (primary) CD4+ lymphocytopenia is a rare entity and its pathogenesis and genetics are not yet known. The literature was reviewed, in particular for severe alterations in B and CD8+28+ cells and for the role of NF-kappa B and p56(lck) in the immunopathogenesis. Whether the underlying mechanism in idiopathic CD4+ lymphocytopenia is found or not, these patients who present with severe symptoms of a combined immunodeficiency must be treated with intravenous immunoglobin regularly until they have a compatible donor for bone marrow transplantation.