Cytotoxic properties of five Centaurea L. species from Anatolia
Makaleler > Tam Makale · 2011
Yazarlar: Şüra BAYKAN, S Demir, F Aydın Kose, Petek BALLAR KIRMIZIBAYRAK, Canan KARAALP
Planta Medica, Uluslararası, Wos, 2011, cilt 77
Özet
The genus Centaurea L. (Asteraceae) comprises about 192 taxons in the flora of Turkey distributed througout the Anatolian peninsula, with 61% being endemic (1–3). Many species of the genus have long been used traditionally to treat various ailments e.g. cough, hemoroid, peptic ulser and abscess (4). Pharmacological studies on some Centaurea species have reported antiinflammatory, antimicrobial, antipyretic, cytotoxic and immunological activities (5). In this study, methanolic extracts of five Centaurea L. species ( C. aphrodisea Boiss., C. athoa DC, C. hyalolepis Boiss., C. iberica Trev. and C. polyclada DC) were investigated for their cytotoxic activities against three human cancer cell lines; MCF7 (human breast cancer), A549 (human lung cancer), U20S (human osteocarcoma) and one non-cancer cell line, 293HEK (human embriyonic kidney) by cell proliferation assay using WST-1 reagent. C. polyclada extract was the most active one against MCF7 (IC50:61µg/ml), U2OS (IC 50 : 63µg/ml) and 293HEK (IC 50 :72µg/ml) cell lines. C. aphrodisea also showed significant effect on 293HEK (IC 50 :85µg/ml) and MCF7 (IC 50 :90µg/ml). This is the first cytotoxic activity report for the Centaurea species mentioned above.