A SINGLE INSTITUTIONAL EXPERIENCE: Is Epoetin Alpha Effective in Anemic Children with Cancer?
Makaleler > Tam Makale · 2004
Yazarlar: D YILMAZ, NAZAN ÇETİNGÜL, Mehmet KANTAR, H ONIZ, Savaş KANSOY, Ramazan Kaan KAVAKLI
Pediatric Hematology and Oncology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2004, cilt 21, ss 1-8
DOI: 10.1080/08880010490263281
Özet
The authors aimed to investigate the efficacy of epoetin-alpha on hemoglobin levels and red cell transfusion requirement in children with both hematologic malignancy (HM, n = 27) and solid tumors (ST, n = 14). Epoetin-alpha was given (150 U/kg or 250 U/kg, thrice weekly) for 12 weeks. Epoetin alpha significantly increased the hemoglobin levels at the 2nd and 3rd months of therapy (p <.05). At the 3rd month, the patients required less red cell transfusion. At the dose of 150 U/kg, only three patients with HM, but none of the ST patients, required red cell. However, none required red cell transfusion after 2nd month on epoetin alpha 250 U/kg. Epoetin-alpha administration increases hemoglobin levels and decreases red cell transfusion requirement in children with malignancy.