Allopurinol hypersensitivity syndrome as a cause of hepatic centrilobular hemorrhagic necrosis
Makaleler > Tam Makale · 2003
Yazarlar: Emine Nihal METE GÖKMEN, Funda YILMAZ BARBET, Okan GÜLBAHAR, Ahmet AYDIN, Aytül Zerrin SİN, Ali KOKULUDAĞ, G YUCE, F SEBIK
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2003, cilt 13, ss 281-283
Özet
Extensive and severe hepatic centrilobular hemorrhagic necrosis is a common finding in hepatic vein obstruction and Budd-Chiari syndrome. Some drugs, including allopurinol, can also cause this histopathologic appearance but to our knowledge in this setting the lesions are not so massive. Here we report a case of a 41-year-old female who developed fever, pruritic skin rash, jaundice, eosinophilia, abnormal liver function tests, and acute renal failure 3 weeks after the beginning of allopurinol treatment, complicated with severe hepatocyte necrosis around most terminal hepatic venules suggesting Budd-Chiari syndrome.