Risk assessment of Organophosphate Pesticide Exposure on Greenhouse Workers in Menderes Region,Develi Village
Articles > Article · 2004
Authors: Ferah SAYIM, Nefise Ülkü KARABAY YAVAŞOĞLU
Journal of Medical Sciences, Refereed Journals of Other Institutions, International, 2004, vol 24, pp 6-11
Summary
<p><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">BSTRACT<br></b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"></span><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">Objective:</b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"> Plasma cholinesterase (PChE) activities are widely used to determine the rate of exposure to organophosphate (OP) pesticides. The aim of our study was to determine the existence of any symptomatic and biochemical effects of OP pesticide exposure during pesticide application in workers. </span><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">Material and Methods:</b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"> Blood samples were collected from 53 male greenhouse workers exposed to pesticides for 2-30 years in Develi Village. PChE levels were determined spectrophotometrically and chromatographic analysis were carried out on (gas chromatography/nitrogen phosphorus detector) (GC/NPD) for residue analysis. </span><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">Results:</b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"> A decrease in PChE levels was observed (mean ± SD; 878 ± 90.2 nmol/min/mL plasma) when compared to control (mean±SD; 1706 ± 102.4 nmol/min/mL plasma). Symptoms were nausea, eye irritation and ophthalmia, headache, fatigue and anorexia, skin disease, coughing, gasping for breath and asthma, dizziness and coma. No organophosphate pesticide residue was detected in blood specimens of the workers. </span><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">Conclusion:</b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"> Significant inhibition of PChE activity and clinical symptoms were observed in the workers, indicating a potential toxicological hazard from OP pesticide exposure.</span><br style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"><br style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;"><b style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">Keywords</b><span style="color: rgb(34, 34, 34); font-family: Verdana, sans-serif; font-size: 11px; line-height: 18px; text-align: justify;">: Organophosphate insecticide, worker, plasma cholinesterase activity, residue analysis</span><br></p>