Promoter hypermethylation-mediated down-regulation of RUNX3 gene in human brain tumors
Articles > Article · 2013
Authors: Çığır BİRAY AVCI, Y Dodurga, Sunde YILMAZ SÜSLÜER, ZO Sıgva, M Yucebas, HO Caglar, Taner AKALIN, T Dalbasti, N Oktar, C Gunduz
Irish Journal of Medical Science, Journal Indexed in SCI Expanded, International, WoS, 2013, vol 183, pp 259-264
DOI: 10.1007/s11845-013-1001-3
Summary
Background The Runx family proteins, including RUNX3, are tissue-restricted transcription factors and play role in neuronal development and tumorigenesis. RUNX3 has an important role in glioblastoma (GBM) tumorigenesis because of its promoter hypermethylation.