Plasma Interleukin-7 (IL-7) and IL-8 Concentrations in Acute Rheumatic Fever and Chronic Rheumatic Heart Disease
Makaleler > Tam Makale · 1995
Yazarlar: Necil KÜTÜKÇÜLER, N NARIN
Scandinavian Journal of Rheumatology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 1995, cilt 24, ss 383-385
DOI: 10.3109/03009749509095185
Özet
Interleukin-7 (IL-7) and IL-8 productions in 25 children with acute rheumatic fever (ARF) and in 15 children with chronic rheumatic heart disease (CRHD) and in 15 children with streptococcal pharyngitis (SP), were investigated in order to determine whether they have a role in the pathogenesis of rheumatic fever. Significantly higher IL-8 levels were found in ARF patients in the clinically active period. IL-7 concentrations remained unchanged during different stages of rheumatic fever. The decrease of elevated IL-8 concentrations within 3 months and normal IL-8 concentrations in patients with CRHD and SP indicate an excessive production of IL-8, probably by cellular infiltrates in the joint throughout the active period of rheumatic disease.