Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats
Makaleler > Tam Makale · 2015
Yazarlar: Derya İLEM ÖZDEMİR, Oya Caglayan-Orumlu, MAKBULE AŞIKOĞLU, Hayal Ozkilic, Fethiye Ferda YILMAZ, Mine Hosgor-Limoncu
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2015, cilt 308, ss 995-1004
DOI: 10.1007/s10967-015-4516-4
Özet
Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of Tc-99m-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of Tc-99m-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.