Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox
Makaleler > Tam Makale · 2010
Yazarlar: Masallah BARAN, Funda ÇETİN, Omer BERK, Demir GOKCE, Ramazan Kaan KAVAKLI, Funda YILMAZ BARBET, Sait ŞEN, Rasit Vural YAGCI
TURKISH JOURNAL OF GASTROENTEROLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2010, cilt 21, ss 448-451
Özet
Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.