The Effects of Combination Therapy of Ionizing Radiation and Oncolytic Viruses
Makaleler > Tam Makale · 2021
Yazarlar: Meliha EKİNCİ, Derya İLEM ÖZDEMİR
Fabad Journal of Pharmaceutical Sciences, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2021, cilt 46, ss 79-92
Özet
cancer is the leading cause of death worldwide. treatment methods in cancer consist of radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. ionizing radiation therapy, which deprives cancer cells of its ability to reproduce, remains an important component of cancer treatment, with about 50% of all cancer patients receiving radiation therapy during the disease, and contributes to 40% of curative treatment for cancer. Due to the side effects of these routine cancer treatments, the need for new therapeutic strategies has increased. with the development of oncolytic viruses in the last 20 years, a new area called virotherapy has been created in the treatment of cancer. Oncolytic viruses are a new biological therapeutic group with a wide spectrum of anticancer activity, with low human toxicity. studies have shown that oncolytic viruses, which can be designed to selectively infect and / or multiply in cancer cells, have an increased antitumoral effect on tumor xenografts combined with ionizing radiation. in this review, treatment methods with ionizing radiation and oncolytic viruses are described and examples from current studies are presented.