Analysis of androgen regulated homeobox gene NKX3.1 during prostate carcinogenesis
Makaleler > Tam Makale · 2004
Yazarlar: CG Korkmaz, Kemal Sami KORKMAZ, J Manola, ZJ Xi, B Risberg, H Danielsen, J Kung, WR Sellers, M Loda, F Saatcioglu
JOURNAL OF UROLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 172, ss 1134-1139
DOI: 10.1097/01.ju.0000136526.78535.b8
Özet
Purpose: NKX3.1 is an androgen regulated gene that is largely specific to the prostate for expression and it is predicted to encode a homeobox protein. Null alleles of NKX3.1 in mice results in impaired prostate development as well as hyperplasia and dysplasia of the prostate. In addition, the NKX3.1 gene maps to a region of high loss of heterozygosity in prostate cancer in humans, suggesting that NKX3.1 might have a direct role in prostate carcinogenesis, possibly functioning as a tumor suppressor protein. Previous studies of the levels of NKX3.1 mRNA or protein in prostate cancer specimens have resulted in conflicting findings.