Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor beta 1 Deficiency
Makaleler > Tam Makale · 2013
Yazarlar: Monia Ouederni, Ozden Sanal, Aydan Ikinciogullari, Ilhan Tezcan, Figen Dogu, Ithaisa Sologuren, Sigifredo Pedraza-Sanchez, Melike Keser, Gonul Tanir, Chris Nieuwhof, Elena Colino, Dinakantha Kumararatne, Jacov Levy, Necil KÜTÜKÇÜLER, Caner Aytekin, Estefania Herrera-Ramos, Micah Bhatti, Neslihan KARACA, Ridha Barbouche, Arnon Broides, Ekaterini Goudouris, Jose Luis Franco, Nima Parvaneh, Ismail Reisli, Alexis Strickler, Anna Shcherbina, Ayper Somer, Anthony Segal, Alfonso Angel-Moreno, Jose Luis Lezana-Fernandez, Mohamed Bejaoui, Miriam Bobadilla-Del Valle, Salem Kachboura, Timothy Sentongo, Imen Ben-Mustapha, Jacinta Bustamante, Capucine Picard, Anne Puel, Stephanie Boisson-Dupuis, Laurent Abel, Jean-Laurent Casanova, Carlos Rodriguez-Gallego
CLINICAL INFECTIOUS DISEASES, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2013, cilt 58, ss 204-213
DOI: 10.1093/cid/cit722
Özet
Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency.