Clostridial collagenase aggravates the systemic inflammatory response in rats with partial-thickness burns
Articles > Article · 2008
Authors: Ülküm Zafer DÖKÜMCÜ, Mustafa Orkan ERGÜN, Handan AK, Sohret AYDEMIR, Murat SEZAK, Mehmet Geylani ÖZOK, Ahmet ÇELİK
BURNS, Journal Indexed in SCI Expanded, International, 2008, vol 34, pp 935-941
DOI: 10.1016/j.burns.2008.01.001
Summary
Aim: Clostridial collagenase A (CCA) has been shown effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns. As there are also reports of fever, leukocytosis, increased C-reactive protein (CRP) levels and septic complications during treatment with CCA, we aimed to determine in rats whether CCA aggravates the systemic inflammatory response.