T-cell subsets and interleukin-6 response in Rasmussen's encephalitis
Makaleler > Tam Makale · 2005
Yazarlar: Hasan TEKGÜL, MUZAFFER POLAT, Ömer KİTİŞ, GÜL AKTAN, AYŞE FAHRİYE TOSUN, SEMİHA TERLEMEZ, Necil KÜTÜKÇÜLER, YUSUF ERŞAHİN, SARENUR GÖKBEN
PEDIATRIC NEUROLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2005, cilt 33, ss 39-45
DOI: 10.1016/j.pediatrneurol.2005.01.007
Özet
To evaluate the immunopathogenesis in Rasmussen's encephalitis, peripheral lymphocyte subsets and interleukin-6 analysis were performed in three patients. Magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging were performed to assess neuronal injury in the affected hemisphere. Before initiation of immune therapy, percentage of cytotoxic T cells was found to be increased in peripheral blood obtained from patients compared with a group of age-matched normal control subjects. During follow-up, percentage of cytotoxic T cells returned to the normal ranges only in one patient who had an early functional hemispherectomy. All three patients had significantly increased interleukin-6 concentration in cerebrospinal fluid and serum compared with the mean values of patients with acute viral encephalitis. The magnitude of interleukin-6 response in the patients correlated with the neuronal loss and atrophy on magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging studies. The patient, who had a fulminant course and an early hemispherectomy, had higher interleukin-6 concentration in cerebrospinal fluid and serum than those of the other two.