In vitro synergistic efficacy of conjugated linoleic acid, oleic acid, safflower oil and taxol cytotoxicity on PC3 cells
Articles > Article · 2014
Authors: Sadi Kizilsahin, Ayşe NALBANTSOY, Nefise Ülkü KARABAY YAVAŞOĞLU
NATURAL PRODUCT RESEARCH, Journal Indexed in SCI Expanded, International, WoS, 2014, vol 29, pp 378-382
DOI: 10.1080/14786419.2014.945172
Summary
The aim of this study was to determine in vitro synergistic efficacy of conjugated linoleic acid (CLA), oleic acid (OLA), safflower oil and taxol (Tax) cytotoxicity on human prostate cancer (PC3) cell line. To determine synergistic efficacy of oil combinations, PC3 treated with different doses of compounds alone and combined with 10 mu g/mL Tax. The MTT results indicated that OLA-Tax combinations exhibited cytotoxicity against PC3 at doses of 30nM+10 mu g-Tax, 15nM+5 mu g-Tax and 7.5nM+2.5 mu g-Tax. The treatment of OLA or Tax did not show significant inhibition on PC3, while OLA-Tax combinations showed effective cytotoxicity at treated doses. CLA-Tax combinations demonstrated the same effect on PC3 as combined form with 45.72% versus the alone form as 74.51% viability. Cytotoxic synergy between Tax, OLA and CLA shows enhanced cytotoxicity on PC3 which might be used in the therapy of prostate cancer.