Nitric oxide and the endothelium: History and impact on cardiovascular disease
Articles > Article · 2006
Authors: Günay YETİK ANACAK, John D. CATRAVAS
VASCULAR PHARMACOLOGY, Journal Indexed in SCI Expanded, International, 2006, vol 45, pp 268-276
DOI: 10.1016/j.vph.2006.08.002
Summary
There are few discoveries with the magnitude of the impact that NO has had on biology during the 25 years since its discovery. There is hardly a disease today not associated with altered NO homeostasis. In fact, despite numerous other endothelial functions, endothelial dysfunction has become synonymous with reduced biological activity of NO.