Effect of microemulsion formulation on biodistribution of<sup>99m</sup>Tc-Aprotinin in acute pancreatitis models induced rats.
Makaleler > Tam Makale · 2016
Yazarlar: Derya İLEM ÖZDEMİR, Neslihan Ustundag-Okur, Zeynep Ay Senyigit, Nevin ORUÇ, Makbule Asikoglu, Ahmet Ömer ÖZÜTEMİZ, Hatice Yeşim KARASULU
DRUG DELIVERY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2016, cilt 23, ss 3055-3062
DOI: 10.3109/10717544.2016.1145306
Özet
Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory condition of the pancreas that is painful and at times deadly. Over the following two decades Aprotinin therapeutic potential on pancreatitis is proven experimentally, its clinical therapeutic success is limited due to low targeting to pancreas.