Exploiting the extemporaneousness of radiopharmaceuticals: Radiolabeling stability under diverse conditions
Makaleler > Tam Makale · 2022
Yazarlar: André Damasceno, Martha Sahylí Ortega Pijeira, Eduardo Ricci-Junior, Luciana Magalhães Rebelo Alencar, Derya İLEM ÖZDEMİR, Ralph Santos-Oliveira
Journal of Pharmaceutical and Biomedical Analysis, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2022, cilt 221, ss 115024-115024
DOI: 10.1016/j.jpba.2022.115024
Özet
Radiopharmaceuticals are radioactive drugs, with a very short shelf life, in most of the cases. The number of proceedings using radiopharmaceuticals increases each day worldwide and for many countries the price of radiopharmaceuticals can represent a limitation in the offer of this drug for more patients. Nonetheless, the shortage of important radionuclides is a serious issue and may also affect the use and distribution of these drugs for more patients globally, especially in low and middle income countries. In this direction, the need to avoid waste of these drugs is crucial. In this study we have evaluated the stability of two radiopharmaceuticals (MDP and DTPA) under different conditions in order to propose the extension of shelf life. The results showed that is possible to have stable radiopharmaceuticals (both MDP and DTPA) even 24hs post labeling process when storage properly. The data may represent an advance in the field of Radiopharmacy, providing news perspectives for radiopharmaceuticals shelf life.