Zeki TOPÇU
Eczacılık Fakültesi, Eczacılık Teknolojisi Bölümü, Farmasötik Biyoteknoloji Anabilim Dalı
Research areas: Health Sciences, Natural Sciences, Pharmacology and Therapeutics, Basic Pharmaceutics Sciences, Life Sciences, Molecular Biology and Genetics, Cytogenetic, Biochemistry, Chemistry, Medicine
Publications
- Selected ellipticine derivatives, known to target topoisomerase II, suppress the alternative lengthening of telomere (ALT) pathway in telomerase-negative cells (2020)
- Effect of Nick Formation on Dna Substrates Via UV-Irradiation on the Kinetic Parameters of Mammalian DNA Topoisomerase 1 (2019)
- Study of the hTopoI/YB1 complex in relation to anti-cancer drug resistance (2017)
- Maya ve Hibrit Teknolojilerinin Eczacılıktaki Uygulamaları (2017)
- Rekombinant DNA Teknolojisinin Sağlık Bilimlerindeki Uygulamaları ile Öne Çıkan Biyoetik Tartışmalar (2017)
- Critical time point for apoptotic cell death in an experimental ischemia/reperfusion model and the effect of N-acetylcystein (2017)
- Novel ellipticine derivatives synthesis and effects on DNA cleavage mediated human topoisomerase II (2016)
- GCN5 participates in ADA3 partnership as revealed with yeast hybrid (2016)
- TELOMERIC ARCHITECTURE AND TELOMERE MAINTENANCE IN RELATION TO THE PROBLEMS ASSOCIATED WITH CONVENTIONAL TELOMERASE TARGETING (2015)
- DNA telomerik yapıları ve telomeraz (2015)
- DNA Cleavage induced by topoisomerase targeted drugs (2015)
- The interference of piperidinopropionaphthone hydrochloride in mammalian type I and type II DNA topoisomerase reactions (2015)
- Experimental Ischemia Reperfusion Model in Relation to Apototic Cell Death (2013)
- The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity (2012)
- The Effects of Arolycoricidine and Narciprimineon Tumor Cell Killing and Topoisomerase Activity (2012)
- Investigation of the expression of light dependency of a Chlamyopsin family gene, COP5, in Chlamydomonas reinhardii (2011)
- Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition (2011)
- Oxidative stress in relation to telomere length maintenance in vascular smooth muscle cells following balloon angioplasty (2010)
- The mRNA expression of cytochrome P450 isoforms in human gastric tissue. (2010)
- Interindividual Difference in CYP2A6 Genotypes as Determined with Restrictional Fragment Length Polymorphism in Relation to GSTM1 and GSTT1 Genes Among the Patients with Prostate Carcinoma (2009)
- Tavşanlarda Balon Hasarı Sonrası Damar Düz Kas Hücrelerinde Telomer Devamlılığı ve Oksidan Stresin Rolü (2009)
- Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells (2009)
- Telomeric restriction analysis of vascular smooth muscle cells following balloon angioplasty in rabbits (2009)
- Cytotoxic activity of 4 '-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I (2009)
- Telomere Length Regulation of Vascular Smooth Muscle Cells in a Balloon Injury Model Effects of Oxidative Stress (2008)
- Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays (2008)
- Flavonoids in Helichrysum pamphylicum Inhibit Mammalian Type I DNA Topoisomerase (2008)
- Mutant Telomeric Repeats in Yeast Can Disrupt the Negative Regulation of Recombination-Mediated Telomere Maintenance and Create an Alternative Lengthening of Telomeres-Like Phenotype (2008)
- SYNTHESIS AND KINETIC EVALUATION OF 1H BENZIMIDAZOLE DERIVATIVES AS MAMMALIAN DNA TOPOISOMERASE I INHIBITORS (2007)
- Mide mukozasında sitokrom P450 izoenzim CYP2A6 nın ekspresyonunun araştırılması (2007)
- Synthesis And Evaluation of Some 1H Benzimidazole Derivatives Topoisomerase I Inhibitors (2007)
- Effects of Chain Length And The Alkyl Groups On The Inhibitory Activity of Bisbenzimidazoles In DNA Topoisomerase I Supercoil Relaxation Activity (2007)
- RT-PCR-based cytochrome P450 expression profile of oral tissue samples (2007)
- Comparative Cytochrome P450-1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level (2006)
- Recombinational telomere elongation in telomerase deletion mutant of Kluveromyces lactis (2005)
- Telomere length regulation in the proliferation of vascular smooth muscle cells (2005)