Evaluation of In Vitro Antidiabetic Activities of Thymus sipyleus subsp. sipyleus var. sipyleus
Project no. 29738 · Status: Kapanmış · 2023
Summary
<p>The Lamiaceae (Labiateae) family, which contains essential oil plants, is generally specific to Mediterranean countries, and the Thymus (thyme) species it contains are plants that have been used in traditional medicine for many years. In addition to the generally known effect of these species being antiseptic, they also have antimicrobial, sedative, abortifacient, and blood circulation stimulating activities. Thyme species have antibacterial, antifungal, antiviral, antiparasitic, spasmolytic, and antioxidant properties due to the effective secondary metabolite groups such as monoterpenes, sesquiterpenes, diterpenes, aldehydes, ketones, alcohols, flavonoids, and phenolic compounds. They are used in hypertension, cholesterol, and cardiovascular system disorders.</p><p>Diabetes mellitus (DM) is one of the top chronic diseases in the world in terms of the number of patients and the economic problems it creates. It is a disease that prevents protein, fat, and carbohydrate metabolism and has Type I and Type II types. Researching herbal products that mimic the mechanism of synthetic drugs used in treatment and may have fewer side effects has become increasingly important. Essential oil extraction, composition of essential oil, and various biological activities of Thymus species are widely reported in the literature. Although there are similar studies on the T. sipyleus species included in our study, there is no report on the evaluation of its antidiabetic activity. Accordingly, it was aimed to examine the in vitro α-amylase and α-glucosidase inhibitor potentials of extracts prepared with different solvents of the species.</p>