Gıdalara Lezzet Artırıcı Olarak Eklenen Monosodyum Glutamatın Erektil Fonksiyon Üzerine Etkileri
Project no. 23616 · Status: Kapanmış · 2022
Summary
<p>Obesity/metabolic syndrome is a crucial public health problem in the prevalence of vascular disorders. Monosodium glutamate(MSG) is a widely used food additive to enhance flavor in food processing and cooking. The effect of MSG on the functional responses of the corpus cavernosum(CC) was investigated with an isolated organ bath. It was aimed to show the effects of MSG on erectile function and to draw attention to health problems. Erectile function is the neurovascular response and the realization of an erection by relaxation of the CC. Erectile dysfunction is a condition of impaired ability to achieve/maintain an erection and it is estimated that there will be 322 million patients in 2025. NO(cGMP-mediated gasotransmitter) relaxes CC and decreased NO bioavailability results in erectile dysfunction. MSG causes metabolic syndrome, obesity, sexual and behavioral dysfunction in animal models. While it has been reported to impair in vivo/in vitro vascular responses and reproductive function in men, its effect on the functional responses of the CC has not been demonstrated. The aim is to elucidate for the first time the effect of MSG on the contraction and relaxation responses of the CC. In the presence/absence of different doses of MSG(3-10-30-100mM); the contractile responses of the receptor-independent potassium chloride and the α1-receptor agonist phenylephrine were obtained, and it was observed that it reduced smooth muscle contractions at high doses(30-100mM). It was observed that the relaxations of acetylcholine which produces NO-mediated relaxation with M3 receptors are decreased, and the responses of sodium nitroprusside, which produced direct relaxation independent of the receptor, were also diminished. The decrease in relaxation suggested that high-dose MSG impairs NO bioavailability/NO-mediated mechanisms by causing endothelial damage. The decrease in contractile response may be due to MSG-induced smooth muscle dysfunction. This is a preliminary study showing for the first time the effect of MSG added in high amounts to packaged foods and fast food on CC. Our next goal is to elucidate the mechanism of dysfunction in receptor-dependent/independent relaxation and contraction responses</p>