Comparison of High-Flow Nasal Cannula Oxygen Therapy and Standard Low-Flow Oxygen Therapy via Face Mask İn Children Diagnosed with Acute Bronchiolitis
Project no. 81 · Status: Kapanmış · 2017
Summary
This study was aimed to determine whether high-flow nasal cannula oxygen therapy (HFNCOT) provided enhanced respiratory support in bronchiolitis than standard oxygen therapy via face mask (SOT). We conducted a prospective, randomized controlled trial in children between 1-24 months of age diagnosed with moderate to severe bronchiolitis requiring oxygen therapy. Participants received either SOT (6-10 L/min) or HFNCOT (2 L*kg/min with oxygen fraction=40%). Primary outcomes were the time heart (HR), respiratory rate (RR), and clinical respiratory score [(CRS); time that took to regress from baseline score to a lower severity score] return to their normal range for age. Secondary outcomes were changes in HR, RR, and CRS. We also examined the length of stay (LOS) and oxygen therapy (LOOT), treatment failure, and adverse event (AE). Compared with SOT, HFNCOT not only shortened the time that HR [2.0 hours (1.0-4.0) vs. 12.0 hours (2.0-24.0)], and RR [4.0 hours (2.0-12.0) vs. 24.0 hours (4.0-48.0); P<0.001] baseline values reached their normal range for age. Additionally, it also regressed CRS to a lower score in less time [2.0 hours (1.0-4.0) vs. 4.0 hours (2.0-24.0); P=0.003]. HFNCOT shortened LOOT compared with SOT [19.0 hours (4.0-30.0) vs. 29.5 hours (14.0-45.7); P=0.009]. Treatment failure was higher in SOT than HFNCOT. No differences were in LOS and AEs rate. The use of HFNCOT may provide enhanced respiratory support, with more rapid HR, RR, and CRS improvements than SOT over time. Comprehensive studies are needed to assess the efficacy and safety of HFNCOT.