MORFOLİN İÇEREN YENİ KİRAL LİGANDLARIN SENTEZLENMESİ ve ASİMETRİK HENRY TEPKİMESİNDEKİ UYGULAMASI
Project no. 20976 · Status: Kapanmış (Yayın bekleniyor) · 2019
Summary
In this thesis, a synthetic approach to morpholine-containing chiral Schiff base ligands is described. Using this approach, three Schiff base ligands were prepared in five steps from phenylalinol. In the final Schiff base formation step, salicylaldehyde, 2,4-dihydroxybenzaldehyde and 2,5-dihydroxybenzaldehyde were used. The ligands were characterised using IR, 1H and 13C NMR spectroscopy and high resolution mass spectrometry. Although two of the Schiff base ligands were active as catalysts for the asymmetric Henry reaction, it was observed that the presence of additional phenolic hydroxy groups did not provide a beneficial effect.