Determination of antiangiogenic potential and in vitro antioxidant capacity of an isoflavonoid with phytoestrogen effect
Project no. 21853 · Status: Kapanmış (Yayın bekleniyor) · 2020
Summary
Characterized by uncontrolled growth, the formation of angiogenic new vessels, the spread of metastatic abnormal cells and programmed cell death, cancer is a disease group that includes highly complex processes, as well as a time-consuming, costly treatment and a disease that reduces the quality of life of individuals in terms of side effects. Although it is known that chronic inflammation caused by carcinogens, various immune system diseases and long-lasting infections trigger cancer, it has also been shown that it increases angiogenesis and prevents apoptosis. Plants have been used as medicines for thousands of years and today, as well as their traditional use in the treatment of various diseases, plant-derived compounds are considered important resources in the development of new therapeutic agents. Numerous plant-derived pharmaceutical products, especially as alternative therapies, have emerged as a result of investigating the clarification and activity of structures of secondary compounds in plants by developing spectral methods. These compounds have a remarkable precaution for pharmacological properties, including cytotoxic and cancer-inhibiting effects, in diseases such as cancer, which is difficult to treat. In recent years, newly discovered naturally occurring anticancer agents form target compounds because they contain high bioactive compounds. Isoflavonoids belonging to the flavonoid class obtained from plants are phytoestrogenic and show proapoptotic and anti-angiogenic effects against various types of cancer. Prunetin selected as the active ingredient in the project has a phytoestrogenic effect and is similar to isoflavonoids such as daidzein, biochanin A, formononetin, genistein, which are frequently studied in the literature in terms of chemical structure. However, it is aimed to demonstrate the anti-angiogenic and anti-inflammatory activity of prunetin, whose biological activity is very limited, for the first time within the scope of this project. For this purpose, it was aimed to determine possible angiogenesis inhibitor activity and cell-based antioxidant capacity in fertilized chicken eggs. As a result of the studies, it has been proven that prunetin has a strong anioxidant and anti-angiogenic effect. Considering its promising results, it has been revealed that prunetin can be applied to support anti-cancer treatment.