INFLAMMATORY PROFILE IN PATIENTS WITH ACROMEGALY AND HEPATOSTEATOSIS: A COMPARATIVE ANALYSIS OF NUCLEAR FACTOR KAPPA B (NF-κB), CYCLOOXYGENASE-2 (COX-2), MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1), INTERLEUKIN-1β (IL-1β), AND TUMOR NECROSIS FACTOR-ALPHA (TNF-α) LEVELS

Project no. 32989 · Status: Kapanmış (Yayın bekleniyor) · 2025

Summary

<p class="ql-align-justify">Purpose:&nbsp;Inflammation&nbsp;may&nbsp;link&nbsp;growth&nbsp;hormone&nbsp;(GH)/insulin-like&nbsp;growth&nbsp;factor-1&nbsp;(IGF-1)&nbsp;excess&nbsp;to&nbsp;hepatic&nbsp;steatosis&nbsp;in&nbsp;acromegaly.&nbsp;This&nbsp;study&nbsp;compared&nbsp;circulating&nbsp;nuclear&nbsp;factor&nbsp;kappa&nbsp;B&nbsp;(NF-κB)&nbsp;p65,&nbsp;cyclooxygenase-2&nbsp;(COX-2),&nbsp;monocyte&nbsp;chemoattractant&nbsp;protein-1&nbsp;(MCP-1),&nbsp;interleukin-1β&nbsp;(IL-1β),&nbsp;and&nbsp;tumor&nbsp;necrosis&nbsp;factor-alpha&nbsp;(TNF-α)&nbsp;levels,&nbsp;together&nbsp;with&nbsp;the&nbsp;Fibrosis-4&nbsp;(FIB-4)&nbsp;index,&nbsp;in&nbsp;patients&nbsp;with&nbsp;acromegaly&nbsp;versus&nbsp;healthy&nbsp;controls,&nbsp;and&nbsp;according&nbsp;to&nbsp;disease&nbsp;control&nbsp;status.</p><p class="ql-align-justify">Methods:&nbsp;This&nbsp;cross-sectional&nbsp;case-control&nbsp;study&nbsp;enrolled&nbsp;48&nbsp;patients&nbsp;with&nbsp;acromegaly&nbsp;(28&nbsp;controlled,&nbsp;20&nbsp;uncontrolled)&nbsp;and&nbsp;30&nbsp;healthy&nbsp;controls&nbsp;between&nbsp;2023&nbsp;and&nbsp;2025&nbsp;at&nbsp;the&nbsp;Department&nbsp;of&nbsp;Endocrinology,&nbsp;Ege&nbsp;University&nbsp;Faculty&nbsp;of&nbsp;Medicine.&nbsp;Anthropometric,&nbsp;biochemical,&nbsp;and&nbsp;inflammatory&nbsp;biomarker&nbsp;measurements&nbsp;were&nbsp;obtained&nbsp;and&nbsp;FIB-4&nbsp;was&nbsp;calculated.&nbsp;Group&nbsp;comparisons,&nbsp;correlation&nbsp;analyses,&nbsp;logistic&nbsp;regression,&nbsp;and&nbsp;ROC&nbsp;analyses&nbsp;were&nbsp;performed.</p><p class="ql-align-justify">Results:&nbsp;Patients&nbsp;with&nbsp;acromegaly&nbsp;were&nbsp;older&nbsp;and&nbsp;had&nbsp;higher&nbsp;fasting&nbsp;glucose,&nbsp;HbA1c,&nbsp;GH,&nbsp;IGF-1,&nbsp;and&nbsp;FIB-4&nbsp;than&nbsp;controls&nbsp;(all&nbsp;p&lt;0.05).&nbsp;Among&nbsp;inflammatory&nbsp;markers,&nbsp;only&nbsp;IL-1β&nbsp;differed&nbsp;between&nbsp;groups&nbsp;(p=0.030);&nbsp;NF-κB&nbsp;p65,&nbsp;COX-2,&nbsp;MCP-1,&nbsp;and&nbsp;TNF-α&nbsp;were&nbsp;comparable.&nbsp;IGF-1&nbsp;correlated&nbsp;inversely&nbsp;with&nbsp;MCP-1&nbsp;and&nbsp;IL-1β,&nbsp;and&nbsp;a&nbsp;strong&nbsp;positive&nbsp;correlation&nbsp;network&nbsp;emerged&nbsp;among&nbsp;inflammatory&nbsp;markers.&nbsp;Hypertension,&nbsp;HbA1c,&nbsp;IGF-1,&nbsp;and&nbsp;FIB-4&nbsp;were&nbsp;independent&nbsp;factors&nbsp;associated&nbsp;with&nbsp;acromegaly.&nbsp;IGF-1&nbsp;(AUC&nbsp;0.752)&nbsp;and&nbsp;FIB-4&nbsp;(AUC&nbsp;0.686)&nbsp;showed&nbsp;significant&nbsp;discriminative&nbsp;performance&nbsp;(FDR-corrected).&nbsp;FIB-4&nbsp;was&nbsp;higher&nbsp;in&nbsp;controlled&nbsp;than&nbsp;uncontrolled&nbsp;disease,&nbsp;whereas&nbsp;GH&nbsp;and&nbsp;IGF-1&nbsp;were&nbsp;higher&nbsp;in&nbsp;uncontrolled&nbsp;acromegaly;&nbsp;inflammatory&nbsp;markers&nbsp;did&nbsp;not&nbsp;differ&nbsp;by&nbsp;control&nbsp;status.</p><p class="ql-align-justify">Conclusion:&nbsp;Acromegaly&nbsp;is&nbsp;characterized&nbsp;by&nbsp;a&nbsp;higher&nbsp;FIB-4&nbsp;index&nbsp;and&nbsp;an&nbsp;altered&nbsp;inflammatory&nbsp;correlation&nbsp;network,&nbsp;independent&nbsp;of&nbsp;individual&nbsp;cytokine&nbsp;concentrations.&nbsp;FIB-4&nbsp;emerged&nbsp;as&nbsp;an&nbsp;independent&nbsp;factor&nbsp;associated&nbsp;with&nbsp;acromegaly,&nbsp;supporting&nbsp;its&nbsp;potential&nbsp;utility&nbsp;for&nbsp;non-invasive&nbsp;hepatic&nbsp;fibrosis&nbsp;risk&nbsp;assessment.</p>

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