Investigation of genetic susceptibility to the development of invasive bacterial infection in children under three months of age using polymorphism: a 1-year prospective study

Project no. 21975 · Status: Kapanmış (Yayın bekleniyor) · 2020

Summary

Despite all the advancements in medicine and technology, invasive bacterial infections (IBIs) such as meningitis, pneumonia, pyelonephritis, gastroenteritis, and sepsis continue to be frequently observed and result in deaths, both in underdeveloped and developing countries and in developed countries. The period during childhood when these infections are most commonly seen is the age range of 0-3 months. Several reasons have been suggested for the higher incidence of IBIs during this period, including ongoing tissue and organ maturation, incomplete development of the immune system, and incomplete vaccination. However, it is still not fully understood why two individuals of the same age with identical demographic, social, and medical characteristics may have one develop an IBI while the other does not. Genetic differences are believed to play a role in this variation.Many studies have been conducted to identify IBIs after they have developed in cases, and several biomarkers such as C-reactive protein (CRP), Procalcitonin (PCT), Presepsin, and soluble urokinase plasminogen activator receptor (suPAR) have been discovered. However, identifying individuals with genetic susceptibility to IBIs before they occur could significantly reduce IBI-related deaths. Recent advances in the field of genetics have made it easier to obtain genomic DNA from a 2 ml blood sample taken for any reason. Previous studies on a limited number of patients, encompassing all age groups of children, have found an association between TLR4 rs2149356 (c.261-468T>G), LTA gene rs2229094 (c.37T>C), and RFP175 rs1585110 (c.246+8853G>A) gene polymorphisms and IBIs. However, it is not known whether children in the most vulnerable age group of 0-3 months exhibit these genetic characteristics. The aim of our study is to investigate the role of TLR4 rs2149356 (c.261-468T>G), LTA gene rs2229094 (c.37T>C), and RFP175 rs1585110 (c.246+8853G>A) gene polymorphisms in the development of invasive bacterial infections in children under 3 months of age.

View details