Sarcopenia in Children and Adolescents with Type 1 Diabetes Mellitus
Project no. 31973 · Status: Kapanmış (Yayın bekleniyor) · 2024
Summary
<p>Sarcopenia is defined as a syndrome characterized by loss of skeletal muscle mass, reduced muscle strength, and impaired muscle function. Although traditionally associated with older adults, recent evidence indicates that chronic diseases may also lead to sarcopenia in children and adolescents. Type 1 Diabetes Mellitus (T1DM) is a chronic metabolic disorder accompanied by insulin deficiency, metabolic dysregulation, and inflammation, potentially resulting in alterations in muscle structure and function. Therefore, children and adolescents with T1DM may be at increased risk of developing sarcopenia.</p><p>Current literature on pediatric T1DM has primarily evaluated muscle mass and strength; however, there is a lack of comprehensive studies incorporating the combined assessment of muscle mass, muscle strength, and physical performance. The aim of this study is to determine the presence of sarcopenia in children and adolescents with T1DM and to investigate its clinical significance as an important comorbidity.</p><p>This prospective study will include 60 children aged 10–18 years diagnosed with T1DM for at least one year and 60 age- and sex-matched healthy controls, resulting in a total of 120 participants. Muscle mass will be assessed using body composition analysis, muscle strength will be measured using a handgrip dynamometer, and physical performance will be evaluated via a 6-minute walk test. Laboratory markers including HbA1c, lipid profile (TG, TC, LDL-C, HDL-C), and liver function tests (AST/ALT) will be collected from medical records.</p><p>This study aims to provide new evidence for early detection and clinical management of sarcopenia in pediatric T1DM, contributing to improved long-term outcomes in this patient population.</p>