Development of Antiviral Mucoadhesive Oral Film Containing Olive Leaf Extract and Thyme Essential Oil Microcapsules
Project no. 21870 · Status: Kapanmış · 2020
Summary
Previous literature studies determined that essential oil affects viral envelopes and masks viral components that allow them to absorb or enter the host cell. Due to the natural compounds contain olive tree leaves, it has many biological activities such as antioxidant, antithrombotic, and immune system balancing effects. Mucoadhesive delivery systems are more advantageous than other oral delivery systems in many ways. The therapeutic response is provided by releasing the active substance in a controlled and predictable manner. Oral intake of antioxidants causes the hepatic first passage and the enzymes in the digestive system to degrade and decrease their activity. To prevent this, in this research, a novel dual-carrier system, which consists of both encapsulation and mucoadhesive film technologies, was developed. This study aimed to transform thyme essential oil (TEO) into calcium alginate microcapsules and then integrate them into olive leaf extract (OLE) loaded mucoadhesive film prepared by the solvent casting method. Experimental designs for the encapsulation process and optimization of mucoadhesive film formulation were made with Design-Expert software using the Box-Behnken design method. The effects of the electrospraying process parameters including flow rate of the emulsion solution applied potential difference, and distance parameters on average microcapsule diameter, encapsulation efficiency, and encapsulation yield were investigated.