Determination of Muscle Mass Cut-off Values in Turkish Population Using Whole-Body Bone Mineral Densitometry

Project no. 23735 · Status: Kapanmış (Yayın bekleniyor) · 2022

Summary

<p>ABSTRACT</p><p></p><p>Background&nbsp;and&nbsp;Objective:&nbsp;Sarcopenia&nbsp;is&nbsp;a&nbsp;major&nbsp;geriatric&nbsp;syndrome&nbsp;characterized&nbsp;by&nbsp;a&nbsp;decline&nbsp;in&nbsp;muscle&nbsp;mass,&nbsp;muscle&nbsp;strength,&nbsp;and&nbsp;physical&nbsp;performance,&nbsp;leading&nbsp;to&nbsp;functional&nbsp;impairment&nbsp;in&nbsp;older&nbsp;adults.&nbsp;Cut-off&nbsp;values&nbsp;used&nbsp;in&nbsp;the&nbsp;diagnosis&nbsp;of&nbsp;sarcopenia&nbsp;are&nbsp;generally&nbsp;derived&nbsp;from&nbsp;different&nbsp;populations,&nbsp;and&nbsp;inter-population&nbsp;variability&nbsp;may&nbsp;affect&nbsp;diagnostic&nbsp;accuracy.&nbsp;The&nbsp;aim&nbsp;of&nbsp;this&nbsp;study&nbsp;was&nbsp;to&nbsp;determine&nbsp;reference&nbsp;cut-off&nbsp;values&nbsp;for&nbsp;appendicular&nbsp;skeletal&nbsp;muscle&nbsp;mass&nbsp;(ASM)&nbsp;and&nbsp;its&nbsp;derived&nbsp;indices&nbsp;using&nbsp;whole-body&nbsp;dual-energy&nbsp;X-ray&nbsp;absorptiometry&nbsp;(DEXA)&nbsp;in&nbsp;a&nbsp;healthy&nbsp;Turkish&nbsp;young&nbsp;adult&nbsp;population.</p><p>Methods:&nbsp;This&nbsp;cross-sectional&nbsp;study&nbsp;included&nbsp;175&nbsp;healthy&nbsp;volunteers&nbsp;(93&nbsp;women,&nbsp;82&nbsp;men)&nbsp;aged&nbsp;20–45&nbsp;years&nbsp;without&nbsp;known&nbsp;chronic&nbsp;diseases&nbsp;between&nbsp;August&nbsp;2022&nbsp;and&nbsp;July&nbsp;2025.&nbsp;Muscle&nbsp;mass&nbsp;was&nbsp;measured&nbsp;using&nbsp;DEXA;&nbsp;handgrip&nbsp;strength&nbsp;was&nbsp;assessed&nbsp;with&nbsp;a&nbsp;dynamometer,&nbsp;and&nbsp;physical&nbsp;performance&nbsp;was&nbsp;evaluated&nbsp;using&nbsp;the&nbsp;4-meter&nbsp;gait&nbsp;speed&nbsp;test.&nbsp;Anthropometric&nbsp;measurements&nbsp;were&nbsp;obtained&nbsp;using&nbsp;standard&nbsp;methods.&nbsp;Statistical&nbsp;analyses&nbsp;included&nbsp;parametric&nbsp;and&nbsp;non-parametric&nbsp;tests,&nbsp;and&nbsp;cut-off&nbsp;values&nbsp;were&nbsp;calculated&nbsp;as&nbsp;1,&nbsp;2,&nbsp;and&nbsp;2.5&nbsp;standard&nbsp;deviations&nbsp;below&nbsp;the&nbsp;young&nbsp;adult&nbsp;mean.</p><p>Results:&nbsp;The&nbsp;mean&nbsp;age&nbsp;of&nbsp;participants&nbsp;was&nbsp;29.85±7.41&nbsp;years.&nbsp;Mean&nbsp;ASM&nbsp;was&nbsp;13.65±2.00&nbsp;kg&nbsp;in&nbsp;women&nbsp;and&nbsp;22.48±2.87&nbsp;kg&nbsp;in&nbsp;men.&nbsp;Handgrip&nbsp;strength&nbsp;was&nbsp;27.76±3.96&nbsp;kg&nbsp;in&nbsp;women&nbsp;and&nbsp;46.07±6.98&nbsp;kg&nbsp;in&nbsp;men,&nbsp;while&nbsp;gait&nbsp;speed&nbsp;was&nbsp;1.19±0.15&nbsp;m/s&nbsp;and&nbsp;1.23±0.17&nbsp;m/s,&nbsp;respectively.&nbsp;Strong&nbsp;positive&nbsp;correlations&nbsp;were&nbsp;observed&nbsp;between&nbsp;ASM&nbsp;and&nbsp;muscle&nbsp;strength&nbsp;as&nbsp;well&nbsp;as&nbsp;anthropometric&nbsp;parameters&nbsp;(p&lt;0.001).&nbsp;The&nbsp;-2&nbsp;SD&nbsp;cut-off&nbsp;values&nbsp;for&nbsp;ASM&nbsp;were&nbsp;9.65&nbsp;kg&nbsp;in&nbsp;women&nbsp;and&nbsp;16.74&nbsp;kg&nbsp;in&nbsp;men,&nbsp;while&nbsp;the&nbsp;-2.5&nbsp;SD&nbsp;values&nbsp;were&nbsp;8.65&nbsp;kg&nbsp;and&nbsp;15.3&nbsp;kg,&nbsp;respectively.</p><p>Conclusion:&nbsp;This&nbsp;study&nbsp;provides&nbsp;DEXA-based&nbsp;reference&nbsp;and&nbsp;cut-off&nbsp;values&nbsp;for&nbsp;muscle&nbsp;mass&nbsp;in&nbsp;a&nbsp;Turkish&nbsp;young&nbsp;adult&nbsp;population.&nbsp;The&nbsp;findings&nbsp;support&nbsp;the&nbsp;importance&nbsp;of&nbsp;using&nbsp;population-specific&nbsp;reference&nbsp;values&nbsp;in&nbsp;the&nbsp;diagnosis&nbsp;of&nbsp;sarcopenia.&nbsp;In&nbsp;addition,&nbsp;muscle&nbsp;mass&nbsp;should&nbsp;be&nbsp;evaluated&nbsp;together&nbsp;with&nbsp;muscle&nbsp;strength&nbsp;and&nbsp;physical&nbsp;performance&nbsp;parameters.&nbsp;The&nbsp;-2.5&nbsp;SD&nbsp;cut-off&nbsp;values&nbsp;may&nbsp;offer&nbsp;a&nbsp;more&nbsp;conservative&nbsp;and&nbsp;clinically&nbsp;useful&nbsp;approach&nbsp;for&nbsp;screening&nbsp;and&nbsp;diagnosis.&nbsp;</p>

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