Determination of the Bioactive Properties of Zinc-Containing Glass Ionomer Cements
Project no. 32107 · Status: Kapanmış · 2024
Summary
<p>Tooth decay is one of the most common chronic diseases in the world. This biofilm-related disease is characterized by mineral loss in tooth tissue and, if left untreated, can lead to tooth loss. When tooth decay progresses to the point of cavity formation, it must be treated with restorative materials, which results in a significant economic burden worldwide. In modern dentistry, the materials used for restoration play an important role not only in the treatment of the disease but also in preventing the formation of secondary caries, thanks to their ion release and antibacterial properties. Bioactive restorative materials claimed to possess these properties and the production of such materials are currently a topic of research. Many studies have been conducted on the release of fluoride ions from materials to prevent secondary caries formation. On the other hand, it has been recognized that zinc release from materials is important in supporting bioactivity, and it is claimed that zinc-containing restorative materials, thanks to their filler Biounion, release zinc ions in addition to fluoride. The aim of this study is to investigate the ion release and antibacterial properties of this material compared to ChemFil Rock, which releases zinc through a different mechanism, and Ketac Molar, a conventional glass ionomer cement. The zinc, aluminum, and potassium ion release properties of glass ionomer cements will be examined using an ICP-MS device on samples taken on the 1st and 6th days after exposing them to fresh solutions in both acidic environments and distilled water for 6 days. To determine the antimicrobial properties of freshly mixed materials, the material will be placed in a well immediately after mixing, and the zone diameter will be measured. In the agar well diffusion method, the same samples used in the ion experiment will be evaluated for their antibacterial properties. In the liquid microdilution method, the minimum inhibitory concentration of the material will be determined.</p><p><br></p>