KARDİYAK BİYOBELİRTEÇLERİN TANINMASINA YÖNELİK YENİ NESİL NANOPOLİMERİK SİSTEMLER
Proje no. 418 · Durum: Kapanmış (Yayın bekleniyor) · 2012
Özet
<p>Ischemic heart diseases is the first reason of deaths especially in high and middle income countries (WHO 2011). Vascular system diseases are also the first reason of deaths in 5 years + deaths in 2012 with the ratio of 37.9 % (TUIK, 2014). Ischemic heart diseases are the first with the 31% ratio. One of three the diagnostic criteria of AMI is, determined by WHO, is the changes in cardiac biomarker levels. In clinical laboratories cardiac biomarkers are detected via monoclonal antibody depended systems. The goal of this study is developing alternative nanopolymeric systems those are crosslinked and containing large surface area due to nano- structure. In this study; nanoparticles with 61 nm diameter and 1222.35 m2/g were obtained. Maximum absorption capacity is 82.17 ng/ml at 0.1 M pH= 2.0 in 35°C . With electrochenical methods, cyclic voltametry and differential pulse voltametry, limit of quantification (LoQ) is 0.14 ng/ml and limit of detection (LoD) is 0.67 ng/ml.</p>